The antitumor effect of magnetic nanodisks and DNA aptamer conjugates

The antitumor effect of magnetic nanodisks and DNA aptamer conjugates

Here we describe a method of forming large arrays (up to 10 9 pieces) of free magnetic Ni-nanodisks 50 nm thick coated on both sides with layers of 5 nm thick Au. The antitumor effect of the magnetic nickel gold-coated nanodisks and DNA aptamer conjugates was evaluated in vivo and in vitro. Under th...

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Veröffentlicht in:Doklady. Biochemistry and biophysics 2016, Vol.466 (1), p.66-69
Hauptverfasser: Kim, P. D., Zamay, S. S., Zamay, T. N., Prokopenko, V. S., Kolovskaya, O. S., Zamay, G. S., Princ, V. Ya, Seleznev, V. A., Komonov, A. I., Spivak, E. A., Rudenko, R. Yu, Dubinina, A. V., Komarov, A. V., Denisenko, V. V., Komarova, M. A., Sokolov, A. E., Narodov, A. A., Zjivaev, V. P., Zamay, A. S.
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Antineoplastic Agents - administration & dosage
Antineoplastic Agents - therapeutic use
Aptamers, Nucleotide - administration & dosage
Aptamers, Nucleotide - therapeutic use
Biochemistry
Biological and Medical Physics
Biomedical and Life Sciences
Biomedical research
Biophysics
Biophysics and Molecular Biology
Carcinoma, Ehrlich Tumor - drug therapy
Cell Line, Tumor
Deoxyribonucleic acid
DNA
Gold - chemistry
Life Sciences
Magnetic Fields
Male
Metal Nanoparticles - adverse effects
Metal Nanoparticles - chemistry
Mice
Mice, Inbred ICR
Nanoparticles
Nickel - chemistry
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Zusammenfassung:Here we describe a method of forming large arrays (up to 10 9 pieces) of free magnetic Ni-nanodisks 50 nm thick coated on both sides with layers of 5 nm thick Au. The antitumor effect of the magnetic nickel gold-coated nanodisks and DNA aptamer conjugates was evaluated in vivo and in vitro. Under the influence of rotating magnetic field, the studied nanodisks can cause the death of Ehrlich ascites carcinoma cells.
ISSN:1607-6729
1608-3091
DOI:10.1134/S1607672916010154