Isolated Peritoneal Donor‐Related Plasmacytoma 3 Years After Liver Transplantation: A Case Report

Organ transplantation carries a risk of disease transmission from donor to recipient, primarily infection or malignancy. Although donors are thoroughly screened, donor‐related malignancies are reported to occur in 0.01% of solid organ transplants. Plasma cell neoplasm, to the best of our knowledge, has not been reported as a donor‐transmitted malignancy in liver transplantation. We describe a liver transplant from a donor with unrecognized plasmacytoma requiring retransplantation. Three years after the first transplant a single peritoneal mass was detected on surveillance imaging and radically excised; HLA phenotyping confirmed the mass to be an isolated extra‐medullary plasmacytoma of chimeric donor and recipient origin. The authors report a case of donor‐related plasmacytoma in a 76‐year‐old man, three years after a liver transplant for hepatocellular carcinoma, that changes an institutional protocol for handling future donor liver biopsies prior to transplantation.