Rituximab as Successful Adjunct Treatment in a Patient With Disseminated Nontuberculous Mycobacterial Infection Due to Acquired Anti-Interferon-  Autoantibody

Rituximab as Successful Adjunct Treatment in a Patient With Disseminated Nontuberculous Mycobacterial Infection Due to Acquired Anti-Interferon-  Autoantibody

An acquired immune deficiency due to interferon gamma (IFN-γ) autoantibodies was diagnosed in a 78-year-old Japanese man with treatment-refractory disseminated nontuberculous mycobacterial infection. In addition to standard antimycobacterial therapy, he was successfully treated with rituximab to eli...

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Veröffentlicht in:Clinical infectious diseases 2014-03, Vol.58 (6), p.E115-e118
Hauptverfasser: Czaja, Christopher A, Merkel, Patricia A, Chan, Edward D, Lenz, Laurel L, Wolf, Molly L, Alam, Rafeul, Frankel, Stephen K, Fischer, Aryeh, Gogate, Shaila, Perez-Velez, Carlos M, Knight, Vijaya
Format: Artikel
Sprache:eng
Schlagworte:
Acquired immune deficiency syndrome
AIDS
Bacteria
Cells
Interferon
Medical treatment
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Zusammenfassung:An acquired immune deficiency due to interferon gamma (IFN-γ) autoantibodies was diagnosed in a 78-year-old Japanese man with treatment-refractory disseminated nontuberculous mycobacterial infection. In addition to standard antimycobacterial therapy, he was successfully treated with rituximab to eliminate B cells and thereby the autoantibody. Subsequently, he obtained a sustained remission from infection. [PUBLICATION ABSTRACT]
ISSN:1058-4838
1537-6591
DOI:10.1093/cid/cit809