Astragaloside IV attenuates apoptosis of hypertrophic cardiomyocyte through inhibiting oxidative stress and calpain-1 activation

Highlights • Astragaloside IV (ASIV) inhibits the apoptosis of hypertrophic cardiomyocyte induced by ISO. • ASIV ameliorates mitochondria dysfunction in heart tissue and cell induced by ISO. • ASIV reduces oxidative stress induced by ISO. • ASIV down-regulates calpain-1 expression and activity....

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Veröffentlicht in:	Environmental toxicology and pharmacology 2015-11, Vol.40 (3), p.764-773
Hauptverfasser:	Mei, Meng, Tang, Futian, Lu, Meili, He, Xin, Wang, Hongxin, Hou, Xuwei, Hu, Jin, Xu, Chonghua, Han, Ronghui
Format:	Artikel
Sprache:	eng
Schlagworte:	2-Propanol - toxicity Animals Antioxidants - administration & dosage Antioxidants - pharmacology Apoptosis Apoptosis - drug effects Astragaloside IV Calpain - metabolism Calpain-1 Cardiomegaly - chemically induced Cardiomegaly - metabolism Cardiomegaly - prevention & control Cardiotonic Agents - pharmacology Cell Line Emergency Gene Expression Regulation - drug effects Hypertrophy Membrane Potential, Mitochondrial - drug effects Mitochondria - drug effects Myocytes, Cardiac - cytology Myocytes, Cardiac - drug effects Myocytes, Cardiac - pathology Oxidation Oxidative Stress - drug effects Rats Rats, Sprague-Dawley Saponins - administration & dosage Saponins - pharmacology Triterpenes - administration & dosage Triterpenes - pharmacology
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Zusammenfassung:	Highlights • Astragaloside IV (ASIV) inhibits the apoptosis of hypertrophic cardiomyocyte induced by ISO. • ASIV ameliorates mitochondria dysfunction in heart tissue and cell induced by ISO. • ASIV reduces oxidative stress induced by ISO. • ASIV down-regulates calpain-1 expression and activity.
ISSN:	1382-6689 1872-7077
DOI:	10.1016/j.etap.2015.09.007