PneuMum: Impact from a randomised controlled trial of maternal 23-valent pneumococcal polysaccharide vaccination on middle ear disease amongst Indigenous infants, Northern Territory, Australia

Highlights • We achieved our intended sample size of 210 participants. • Rates of ear disease (71%) and 23vPPV-type carriage (26%) were lower than expected. • We were unable to show maternal 23vPPV efficacy against infant ear disease or 23vPPV-type carriage. • 23vPPV in pregnancy halved infant ear d...

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Veröffentlicht in:	Vaccine 2015-11, Vol.33 (48), p.6579-6587
Hauptverfasser:	Binks, Michael J, Moberley, Sarah A, Balloch, Anne, Leach, Amanda J, Nelson, Sandra, Hare, Kim M, Wilson, Cate, Morris, Peter S, Nelson, Jane, Chatfield, Mark D, Tang, Mimi L.K, Torzillo, Paul, Carapetis, Jonathan R, Mulholland, E. Kim, Andrews, Ross M
Format:	Artikel
Sprache:	eng
Schlagworte:	23-valent pneumococcal polysaccharide vaccine Adolescent Adult Allergy and Immunology Australia Australian Aboriginal and Torres Strait Islander Peoples Babies Carrier State - epidemiology Carrier State - immunology Carrier State - prevention & control Ear diseases Female Humans Immunity, Maternally-Acquired Immunization Indigenous Infant Infants Nasopharynx - microbiology Northern Territory - epidemiology Otitis media Otitis Media - epidemiology Otitis Media - immunology Otitis Media - microbiology Otitis Media - prevention & control Pneumococcal Infections - epidemiology Pneumococcal Infections - prevention & control Pneumococcal Vaccines - administration & dosage Pneumococcal Vaccines - immunology Pneumococcus Pneumonia Pregnancy Prevalence Streptococcus pneumoniae Streptococcus pneumoniae - immunology Streptococcus pneumoniae - isolation & purification Vaccination Vaccines Young Adult
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Beschreibung
Zusammenfassung:	Highlights • We achieved our intended sample size of 210 participants. • Rates of ear disease (71%) and 23vPPV-type carriage (26%) were lower than expected. • We were unable to show maternal 23vPPV efficacy against infant ear disease or 23vPPV-type carriage. • 23vPPV in pregnancy halved infant ear disease concurrent with 23vPPV-type carriage. • 23vPPV in pregnancy may complement childhood pneumococcal vaccination programs.
ISSN:	0264-410X 1873-2518 1873-2518
DOI:	10.1016/j.vaccine.2015.10.101