Presentation of peptides from Bacillus anthracis protective antigen on Tobacco Mosaic Virus as an epitope targeted anthrax vaccine

Highlights • Anthrax peptides were expressed on Tobacco Mosaic Virus as experimental vaccines. • Vaccines showed cross-reactivity to antibodies raised against native toxin. • Immunized mice developed cross-reactive antibodies to native toxin. • Immunization failed to protect mice or cells in vitro a...

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Veröffentlicht in:	Vaccine 2015-11, Vol.33 (48), p.6745-6751
Hauptverfasser:	McComb, Ryan C, Ho, Chi-Lee, Bradley, Kenneth A, Grill, Laurence K, Martchenko, Mikhail
Format:	Artikel
Sprache:	eng
Schlagworte:	Allergy and Immunology Animals Anthrax Anthrax Vaccines - administration & dosage Anthrax Vaccines - genetics Anthrax Vaccines - immunology Antibodies, Bacterial - blood Antibodies, Neutralizing - blood Antigens Antigens, Bacterial - genetics Antigens, Bacterial - immunology Bacillus anthracis Bacterial Toxins - genetics Bacterial Toxins - immunology Conflicts of interest Cross Reactions Drug Carriers Epitope focused vaccine Epitopes - genetics Epitopes - immunology Female Genetic Vectors Goats Immunoglobulins Infections Kinases Laboratories Mice, Inbred C57BL Neutralization Peptides Protective antigen Proteins Tobacco Mosaic Virus Tobacco Mosaic Virus - genetics Toxins Vaccines Vaccines, Subunit - administration & dosage Vaccines, Subunit - genetics Vaccines, Subunit - immunology Vaccines, Synthetic - administration & dosage Vaccines, Synthetic - genetics Vaccines, Synthetic - immunology Virgaviridae Virus nanoparticle vaccine
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Zusammenfassung:	Highlights • Anthrax peptides were expressed on Tobacco Mosaic Virus as experimental vaccines. • Vaccines showed cross-reactivity to antibodies raised against native toxin. • Immunized mice developed cross-reactive antibodies to native toxin. • Immunization failed to protect mice or cells in vitro against toxin challenge.
ISSN:	0264-410X 1873-2518
DOI:	10.1016/j.vaccine.2015.10.075