Psoriasis: Behind the scenes

Psoriasis is a chronic inflammatory skin disease characterized by a significant deterioration in the quality of life of affected individuals. Notably, psoriasis is significantly associated with cardiovascular and metabolic syndrome and other autoimmune disorders. Recent progress in biologic therapie...

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Veröffentlicht in:	Journal of dermatology 2016-01, Vol.43 (1), p.4-8
Hauptverfasser:	Furue, Masutaka, Kadono, Takafumi
Format:	Artikel
Sprache:	eng
Schlagworte:	Autoimmunity Biological Products - therapeutic use Biological Therapy Humans interleukin-17 interleukin-23 interleukin-36γ Psoriasis Psoriasis - etiology Psoriasis - immunology Psoriasis - therapy tumor necrosis factor-α
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Beschreibung
Zusammenfassung:	Psoriasis is a chronic inflammatory skin disease characterized by a significant deterioration in the quality of life of affected individuals. Notably, psoriasis is significantly associated with cardiovascular and metabolic syndrome and other autoimmune disorders. Recent progress in biologic therapies has revealed the fundamental role of tumor necrosis factor‐α, interleukin (IL)‐23 and the IL‐17A axis together with aberrant overproduction of epidermal IL‐36γ in the pathogenesis of psoriasis. This review provides an update on the clinical, pathological and therapeutic advancements involving psoriasis.
ISSN:	0385-2407 1346-8138
DOI:	10.1111/1346-8138.13186