Identification of novel hereditary cancer genes by whole exome sequencing

Identification of novel hereditary cancer genes by whole exome sequencing

Highlights • Whole exome sequencing (WES) is a powerful tool for medical genetic research. • Novel hereditary cancer genes identified by WES are systematically reviewed. • Challenges of WES studies are discussed.

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Bibliographische Detailangaben
Veröffentlicht in:Cancer letters 2015-12, Vol.369 (2), p.274-288
Hauptverfasser: Sokolenko, Anna P, Suspitsin, Evgeny N, Kuligina, Ekatherina Sh, Bizin, Ilya V, Frishman, Dmitrij, Imyanitov, Evgeny N
Format: Artikel
Sprache:eng
Schlagworte:
Breast cancer
Cancer susceptibility
Disease Susceptibility
Exome
Genes
Genetic Predisposition to Disease
Germ-Line Mutation
Hematology, Oncology and Palliative Medicine
Hereditary cancer syndromes
Humans
Mutation
Neoplasms - genetics
Next generation sequencing
Studies
Whole exome sequencing
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Beschreibung
Zusammenfassung:Highlights • Whole exome sequencing (WES) is a powerful tool for medical genetic research. • Novel hereditary cancer genes identified by WES are systematically reviewed. • Challenges of WES studies are discussed.
ISSN:0304-3835
1872-7980
DOI:10.1016/j.canlet.2015.09.014