A Japanese study to assess immunogenicity and safety of a typhoid Vi polysaccharide vaccine

Highlights • Although rare in Japan, imported cases of typhoid fever can occur in travelers. • Safety and immunogenicity of a typhoid vaccine were assessed in a Japanese population. • The typhoid Vi polysaccharide vaccine, Typhim Vi® , was well tolerated and immunogenic.

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Bibliographische Detailangaben
Veröffentlicht in:	Vaccine 2015-11, Vol.33 (48), p.6697-6702
Hauptverfasser:	Miyazu, Mitsunobu, Kikuchi, Hitoshi, Hamada, Atsuo, Fukushima, Shinji, Ouchi, Kazunobu, Bosch Castells, Valerie, Mihara, Hanako, Bonnet, Marie-Claude
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Allergy and Immunology Antibiotics Antibodies, Bacterial - blood Antigens Binding sites Child Child, Preschool Confidence intervals Drug-Related Side Effects and Adverse Reactions - epidemiology Drug-Related Side Effects and Adverse Reactions - pathology Enzyme-Linked Immunosorbent Assay Female Fever Healthy Volunteers Humans Immunogenicity Industrialized nations Japan Male Middle Aged Polysaccharides, Bacterial - administration & dosage Polysaccharides, Bacterial - adverse effects Polysaccharides, Bacterial - immunology Pregnancy Safety Salmonella Sanitation Treatment Outcome Typhoid Typhoid Fever - prevention & control Typhoid-Paratyphoid Vaccines - administration & dosage Typhoid-Paratyphoid Vaccines - adverse effects Typhoid-Paratyphoid Vaccines - immunology Vaccine Vaccines Waterborne diseases Young Adult
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Beschreibung
Zusammenfassung:	Highlights • Although rare in Japan, imported cases of typhoid fever can occur in travelers. • Safety and immunogenicity of a typhoid vaccine were assessed in a Japanese population. • The typhoid Vi polysaccharide vaccine, Typhim Vi® , was well tolerated and immunogenic.
ISSN:	0264-410X 1873-2518
DOI:	10.1016/j.vaccine.2015.10.086