Programming Bacteriophages by Swapping Their Specificity Determinants

Bacteriophages, bacteria's natural enemies, may serve as potent antibacterial agents. Their specificity for certain bacterial sub-species limits their effectiveness, but allows selective targeting of bacteria. Lu and colleagues present a platform for such targeting through alteration of bacteri...

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Veröffentlicht in:	Trends in microbiology (Regular ed.) 2015-12, Vol.23 (12), p.744-746
Hauptverfasser:	Goren, Moran G, Yosef, Ido, Qimron, Udi
Format:	Artikel
Sprache:	eng
Schlagworte:	Bacteria Bacteria - virology Bacterial Infections - microbiology Bacterial Infections - therapy bacteriophage adsorption Bacteriophages - growth & development Biological Therapy - methods Complementary Therapies - methods host-range expansion host-recognition ligand Humans Internal Medicine shaping bacterial microbiome
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Zusammenfassung:	Bacteriophages, bacteria's natural enemies, may serve as potent antibacterial agents. Their specificity for certain bacterial sub-species limits their effectiveness, but allows selective targeting of bacteria. Lu and colleagues present a platform for such targeting through alteration of bacteriophages’ host specificity by swapping specificity domains in their host-recognition ligand.
ISSN:	0966-842X 1878-4380
DOI:	10.1016/j.tim.2015.10.006