Instability at the FRA8I common fragile site disrupts the genomic integrity of the KIAA0146 , CEBPD and PRKDC genes in colorectal cancer

Highlights • CFS activation may cause recurrent near-centromeric chromosome 8 rearrangements in cancer. • More than 12% of colorectal cancer cell lines harbor copy number alterations at FRA8I. • FRA8I spans 530 kb at 8q11.21 encompassing the KIAA0146 , CEBPD and PRKDC genes. • IGH translocations inv...

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Veröffentlicht in:	Cancer letters 2013-08, Vol.336 (1), p.85-95
Hauptverfasser:	Brueckner, Lena M, Hess, Elisa M, Schwab, Manfred, Savelyeva, Larissa
Format:	Artikel
Sprache:	eng
Schlagworte:	BCP-ALL CCAAT-Enhancer-Binding Protein-delta - genetics Cell Line, Tumor Chromosomal Instability Chromosome Aberrations Chromosome Fragile Sites Chromosomes, Artificial, Bacterial - metabolism Chromosomes, Human, Pair 8 Colorectal Neoplasms - genetics Colorectal Neoplasms - metabolism DNA-Activated Protein Kinase - genetics DNA-PKcs Genome, Human Hematology, Oncology and Palliative Medicine Humans IGH translocation In Situ Hybridization, Fluorescence Isochromosome 8q L1 (LINE) Nuclear Proteins - genetics Nucleic Acid Hybridization Oligonucleotide Array Sequence Analysis Proteins - genetics Translocation, Genetic
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Zusammenfassung:	Highlights • CFS activation may cause recurrent near-centromeric chromosome 8 rearrangements in cancer. • More than 12% of colorectal cancer cell lines harbor copy number alterations at FRA8I. • FRA8I spans 530 kb at 8q11.21 encompassing the KIAA0146 , CEBPD and PRKDC genes. • IGH translocations involve the KIAA0146 gene in a subset of BCP-ALL patients.
ISSN:	0304-3835 1872-7980
DOI:	10.1016/j.canlet.2013.04.007