IDH1, a CHOP and C/EBPβ-responsive gene under ER stress, sensitizes human melanoma cells to hypoxia-induced apoptosis

Highlights • IDH1 was up-regulated in melanoma cells under ER stress. • CHOP and C/EBPβ transcriptionally regulated IDH1 under ER stress. • Elevated IDH1 sensitized human melanoma cells to hypoxia-induced apoptosis and promoted HIF-1α degradation. • CHOP and C/EBPβ affected tunicamycin and hypoxia i...

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Veröffentlicht in:	Cancer letters 2015-09, Vol.365 (2), p.201-210
Hauptverfasser:	Yang, Xuejun, Du, Tongde, Wang, Xiang, Zhang, Yingqiu, Hu, Wanglai, Du, Xiaofeng, Miao, Lin, Han, Chuanchun
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis Apoptosis - drug effects Apoptosis - genetics Binding Sites - genetics CCAAT-Enhancer-Binding Protein-beta - genetics Cell Hypoxia Cell Line, Tumor CHOP DNA-Binding Proteins - metabolism Endoplasmic Reticulum Stress - genetics ER stress Gene Expression Regulation, Neoplastic Hematology, Oncology and Palliative Medicine HIF-1α Humans Hypoxia-Inducible Factor 1, alpha Subunit - metabolism IDH1 Isocitrate Dehydrogenase - biosynthesis Isocitrate Dehydrogenase - genetics Isocitrate Dehydrogenase - metabolism Melanoma - pathology Neoplasm Invasiveness - genetics Promoter Regions, Genetic - genetics RNA Interference RNA, Small Interfering Transcription Factor CHOP - genetics Tunicamycin - pharmacology Up-Regulation
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Zusammenfassung:	Highlights • IDH1 was up-regulated in melanoma cells under ER stress. • CHOP and C/EBPβ transcriptionally regulated IDH1 under ER stress. • Elevated IDH1 sensitized human melanoma cells to hypoxia-induced apoptosis and promoted HIF-1α degradation. • CHOP and C/EBPβ affected tunicamycin and hypoxia induced apoptosis through up-regulating IDH1.
ISSN:	0304-3835 1872-7980
DOI:	10.1016/j.canlet.2015.05.027