Plasma miR-940 may serve as a novel biomarker for gastric cancer

It was reported that circulating microRNAs could be applied as non-invasive biomarkers for cancer monitoring. The purpose of this study was to identify plasma miRNA that may serve as a novel biomarker for gastric cancer and to evaluate its clinical application. MicroRNA profiles were generated from...

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Veröffentlicht in:	Tumor biology 2016-03, Vol.37 (3), p.3589-3597
Hauptverfasser:	Liu, Xin, Kwong, Ava, Sihoe, Alan, Chu, Kent-Man
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Biomarkers Biomarkers, Tumor - blood Biomarkers, Tumor - genetics Biomedical and Life Sciences Biomedicine Cancer Research Cell Line, Tumor Down-Regulation Female Gastric cancer Gene Expression Profiling - methods Gene Expression Regulation, Neoplastic Humans Male Medical diagnosis MicroRNAs MicroRNAs - blood MicroRNAs - genetics Middle Aged Oligonucleotide Array Sequence Analysis Original Article Plasma Reverse Transcriptase Polymerase Chain Reaction Stomach Neoplasms - blood Stomach Neoplasms - genetics Stomach Neoplasms - pathology
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Zusammenfassung:	It was reported that circulating microRNAs could be applied as non-invasive biomarkers for cancer monitoring. The purpose of this study was to identify plasma miRNA that may serve as a novel biomarker for gastric cancer and to evaluate its clinical application. MicroRNA profiles were generated from plasma samples of 5 patients with gastric cancer (GC) versus 5 healthy controls (HC). MicroRNA-940 (miR-940) was one of the most downregulated miRNAs with fold change of 0.164. It was revealed that the expression of miR-940 was downregulated in both the initial set ( N = 30, P
ISSN:	1010-4283 1423-0380
DOI:	10.1007/s13277-015-4019-5