Amino Acid Metabolism is Altered in Adolescents with Nonalcoholic Fatty Liver Disease—An Untargeted, High Resolution Metabolomics Study

Amino Acid Metabolism is Altered in Adolescents with Nonalcoholic Fatty Liver Disease—An Untargeted, High Resolution Metabolomics Study

Objective To conduct an untargeted, high resolution exploration of metabolic pathways that was altered in association with hepatic steatosis in adolescents. Study design This prospective, case-control study included 39 Hispanic-American, obese adolescents aged 11-17 years evaluated for hepatic steat...

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Veröffentlicht in:The Journal of pediatrics 2016-05, Vol.172, p.14-19.e5
Hauptverfasser: Jin, Ran, PhD, Banton, Sophia, MS, MPH, Tran, ViLinh T., PhD, Konomi, Juna V., PhD, Li, Shuzhao, PhD, Jones, Dean P., PhD, Vos, Miriam B., MD, MSPH
Format: Artikel
Sprache:eng
Schlagworte:
Adolescent
Amino Acids - metabolism
Case-Control Studies
Child
Female
Humans
Liver - pathology
Magnetic Resonance Spectroscopy
Male
Metabolomics - methods
Non-alcoholic Fatty Liver Disease - complications
Non-alcoholic Fatty Liver Disease - metabolism
Obesity - metabolism
Pediatrics
Prospective Studies
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Zusammenfassung:Objective To conduct an untargeted, high resolution exploration of metabolic pathways that was altered in association with hepatic steatosis in adolescents. Study design This prospective, case-control study included 39 Hispanic-American, obese adolescents aged 11-17 years evaluated for hepatic steatosis using magnetic resonance spectroscopy. Of these 39 individuals, 30 had hepatic steatosis ≥5% and 9 were matched controls with hepatic steatosis
ISSN:0022-3476
1097-6833
DOI:10.1016/j.jpeds.2016.01.026