Trends in treatment and survival for advanced laryngeal cancer: A 20-year population-based study in The Netherlands

Background The purpose of this study was to determine time trends for primary treatment modalities in advanced laryngeal cancer, overall survival (OS), and laryngectomy‐free interval (LFI) over the last 2 decades in The Netherlands. Methods We conducted an analysis of T3 to T4 laryngeal cancer data from 2 combined national (population‐based and pathology‐based) cancer registries. Results A total of 2072 T3 cases (14.7%) and 1722 T4 cases (12.2%) were identified. Total laryngectomy as primary treatment modality decreased, whereas radiotherapy (RT) increased. For T3 disease, 5‐year OS after primary total laryngectomy (+/− adjuvant RT), RT, and chemoradiotherapy (CRT) was 49%, 47%, and 45%, respectively. For T4 disease, this was 48%, 34%, and 42% (overall p