Enhancement of Virus Replication in An Influenza A Virus NS1-Expresssing 293 Cell Line

The nonstructural protein 1 （NS1） of influenza A virus, which is absent from the viral particle, but highly expressed in infected cells, strongly antagonizes the interferon （IFN）-mediated antiviral response. We engineered an NS1-expressing 293 （293-NS1） cell line with no response to IFN stimulation....

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Veröffentlicht in:	Biomedical and environmental sciences 2016-03, Vol.29 (3), p.224-228
Hauptverfasser:	ZHU, Wu Yang, TAO, Xiao Yan, LYU, Xin Jun, YU, Peng Cheng, LU, Zhuo Zhuang
Format:	Artikel
Sprache:	eng
Schlagworte:	293细胞 A型流感病毒 Cell Line Gene Expression Regulation HEK293 Cells Humans Influenza A virus - physiology NS1蛋白 Viral Nonstructural Proteins - genetics Viral Nonstructural Proteins - metabolism Virus Cultivation - methods Virus Replication - physiology 甲型流感病毒病毒复制病毒粒子细胞株非结构蛋白
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Zusammenfassung:	The nonstructural protein 1 （NS1） of influenza A virus, which is absent from the viral particle, but highly expressed in infected cells, strongly antagonizes the interferon （IFN）-mediated antiviral response. We engineered an NS1-expressing 293 （293-NS1） cell line with no response to IFN stimulation. Compared with the parental 293 cells,
ISSN:	0895-3988 2214-0190
DOI:	10.3967/bes2016.028