Clinical and urodynamic effects of baclofen in women with functional bladder outlet obstruction: Preliminary report

Aim To investigate the efficacy and urodynamic effects of baclofen in women with functional bladder outlet obstruction. Methods Between January 2011 and December 2012, women who underwent baclofen treatment for functional bladder outlet obstruction, defined as 20 cmH2O detrusor pressure at maximum flow rate, but without significant anatomic causes, were retrospectively reviewed. Urodynamic variables at baseline and after 12 weeks of treatment were compared. Results Twenty women with functional bladder outlet obstruction underwent 12 weeks of baclofen treatment (oral baclofen 5 mg, three times daily). All patients reported improvement in voiding dysfunction symptoms after treatment, and no significant adverse effects were found on review of medical records. All patients underwent urodynamic studies after 12 weeks’ treatment. Voided volume, voiding efficiency and maximum flow rate at voiding cystometry were significantly improved (mean, 273 vs. 368 mL, P = 0.002; 62.8% vs. 73.6%, P