Prognostic value of extravascular lung water and its potential role in guiding fluid therapy in septic shock after initial resuscitation

Abstract Purposes To explore whether extravascular lung water (EVLW) provides a valuable prognostic tool guiding fluid therapy in septic shock patients after initial resuscitation. Materials and Methods We performed a retrospective study of septic shock patients who achieved adequate initial fluid resuscitation with extended hemodynamic monitoring, analyzing the prognostic value of EVLW and whether fluid therapy for 24 (T24 ) or24-48 hours (T 24 -48 ) after initial resuscitation with a recommended value of EVLW yielded a 28-day mortality advantage. Results One hundred and five patients with septic shock were included in this study, sixty of whom (57.1%) died after 28 days. For 48 hours after initial resuscitation, the daily fluid balance (DFB)(T24 :2494±1091 vs.1965±964 mL, p=0.011 , andT 24 -48 : 2127±783vs.1588±665 mL, p