Bone status in preterm infant: influences of different nutritional regimens and possible markers of bone disease

Objective: The objective of this study was to evaluate possible influences of parenteral nutrition on growth and bone development in preterms and to search for markers of bone status. Study Design: Metacarpus bone transmission time (mc-BTT) was performed at birth, 21 days and 36 weeks of gestational...

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Veröffentlicht in:	Journal of perinatology 2016-05, Vol.36 (5), p.394-400
Hauptverfasser:	Meneghelli, M, Pasinato, A, Salvadori, S, Gaio, P, Fantinato, M, Vanzo, V, De Terlizzi, F, Verlato, G
Format:	Artikel
Sprache:	eng
Schlagworte:	692/700 692/700/1720 Absorptiometry, Photon - methods Analysis Biochemical analysis Biomarkers - blood Bone Density Bone Development - physiology Bone diseases Bone Diseases - blood Bone Diseases - diagnosis Bone Diseases - prevention & control Bone growth Care and treatment Diagnosis Early Medical Intervention - methods Energy Intake Female Gestational age Growth rate Health aspects Humans Infant Nutritional Physiological Phenomena Infant, Newborn Infant, Premature - growth & development Infant, Premature, Diseases - blood Infant, Premature, Diseases - diagnosis Infant, Premature, Diseases - prevention & control Infants (Premature) Italy Male Markers Medicine Medicine & Public Health Metacarpal Bones - metabolism Metacarpal Bones - pathology Metacarpus Neonates Newborn babies Nutrition original-article Parenteral nutrition Parenteral Nutrition - methods Pediatric Surgery Pediatrics Phosphatemia Phosphates - blood Premature babies Risk factors
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Zusammenfassung:	Objective: The objective of this study was to evaluate possible influences of parenteral nutrition on growth and bone development in preterms and to search for markers of bone status. Study Design: Metacarpus bone transmission time (mc-BTT) was performed at birth, 21 days and 36 weeks of gestational age (GA) in preterms, receiving two different nutritional regimens, together with biochemical analysis. Result: A total of 234 patients were studied. Newborns with aggressive nutrition had significantly better growth rate and higher values of mc-BTT until discharge. Mc-BTT at day 21 correlates positively with nutritional intakes and phosphatemia; lower limb length positively correlated with mc-BTT ( P
ISSN:	0743-8346 1476-5543
DOI:	10.1038/jp.2015.212