Acute and Chronic Ophthalmic Involvement in Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis – A Comprehensive Review and Guide to Therapy. II. Ophthalmic Disease

Abstract Our purpose is to comprehensively review the state of the art with regard to Stevens- Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN), with particular attention to improving the management of associated ocular surface complications. SJS and TEN are two ends of a spectrum of immu...

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Veröffentlicht in:	The ocular surface 2016-04, Vol.14 (2), p.168-188
Hauptverfasser:	Kohanim, Sahar, MD, Palioura, Sotiria, MD, PhD, Saeed, Hajirah N., MD, Akpek, Esen K., MD, Amescua, Guillermo, MD, Basu, Sayan, MBBS, MS, Blomquist, Preston H., MD, Bouchard, Charles S., MD, Dart, John K., DM, FRCOphth, Gai, Xiaowu, PhD, Gomes, José A.P., MD, Gregory, Darren G., MD, Iyer, Geetha, MD, FRCS Glasgow, Jacobs, Deborah S., MD, Johnson, Anthony J., MD, Kinoshita, Shigeru, MD, PhD, Mantagos, Iason S., MD, Mehta, Jodhbir S., MBBS, Perez, Victor L., MD, Pflugfelder, Stephen C., MD, Sangwan, Virender S., MBBS, MS, Sippel, Kimberly C., MD, Sotozono, Chie, MD, PhD, Srinivasan, Bhaskar, MD, MS, Tan, Donald T.H., FRCS, FRCOphth, FAMS, Tandon, Radhika, MD, FRCOphth, FRCSEd, Tseng, Scheffer C.G., MD, PhD, Ueta, Mayumi, MD, PhD, Chodosh, James, MD, MPH
Format:	Artikel
Sprache:	eng
Schlagworte:	amniotic membrane transplantation apoptosis drug-induced disease Epidermis Eye Diseases Humans immune-mediated disease keratinocyte death keratoprosthesis Necrosis ocular surface reconstruction Ophthalmology Quality of Life Skin Stevens-Johnson Syndrome toxic epidermal necrolysis
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Zusammenfassung:	Abstract Our purpose is to comprehensively review the state of the art with regard to Stevens- Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN), with particular attention to improving the management of associated ocular surface complications. SJS and TEN are two ends of a spectrum of immune-mediated disease, characterized in the acute phase by a febrile illness followed by skin and mucous membrane necrosis and detachment. Part I of this review focused on the systemic aspects of SJS/TEN and was published in the January 2016 issue of this journal. The purpose of Part II is to summarize the ocular manifestations and their management through all phases of SJS/TEN, from acute to chronic. We hope this effort will assist ophthalmologists in their management of SJS/TEN, so that patients with this complex and debilitating disease receive the best possible care and experience the most optimal outcomes in their vision and quality of life.
ISSN:	1542-0124 1937-5913
DOI:	10.1016/j.jtos.2016.02.001