Amelioration of cytotoxic effects of aflatoxin by vitamin A: an in vitro study on erythrocytes

We have evaluated the ameliorative role of vitamin A on aflatoxin-induced cytotoxicity in vitro. Aflatoxin (1.95 μ m)-induced hemolysis was found to be significantly reduced on addition of vitamin A (125–1250 IU/ml) in incubation medium. The decrease in hemolysis was almost dose dependent. The kinet...

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Veröffentlicht in:	Toxicology in vitro 2001-02, Vol.15 (1), p.39-42
Hauptverfasser:	Verma, R.J, Shukla, R.S, Mehta, D.N
Format:	Artikel
Sprache:	eng
Schlagworte:	Aflatoxin Aflatoxins - toxicity Amelioration Animals Biological and medical sciences Cytotoxicity Dose-Response Relationship, Drug Drug Interactions Erythrocytes - drug effects Erythrocytes - physiology Food toxicology Fundamental and applied biological sciences. Psychology Hemolysis - drug effects Medical sciences Microbiology Mycology Pathogenicity, host-agent relations, miscellaneous strains, epidemiology Rabbits Toxicology Vitamin A Vitamin A - pharmacology
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Zusammenfassung:	We have evaluated the ameliorative role of vitamin A on aflatoxin-induced cytotoxicity in vitro. Aflatoxin (1.95 μ m)-induced hemolysis was found to be significantly reduced on addition of vitamin A (125–1250 IU/ml) in incubation medium. The decrease in hemolysis was almost dose dependent. The kinetics of reduction of AFB 1 to B 2 and AFG 1 to G 2 by vitamin A has been investigated in dilute aqueous solution at 37°C. The rate of the reduction was found to be first order with respect to the concentration of vitamin A and aflatoxin concentration.
ISSN:	0887-2333 1879-3177
DOI:	10.1016/S0887-2333(00)00058-8