Two clonal types of human skin fibroblasts with different potentials for proliferation and tissue remodeling ability
Highlights • Human dermal fibroblasts were clonally expanded with hypoxic culture without chromosomal aberration. • Comprehensive phenotypic and gene expression profiling revealed heterogeneity among individual fibroblast clones. • Human dermal fibroblasts were categorized into at least two function...
Gespeichert in:
| Veröffentlicht in: | Journal of dermatological science 2016-05, Vol.82 (2), p.84-94 |
|---|---|
| Hauptverfasser: | , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 94 |
|---|---|
| container_issue | 2 |
| container_start_page | 84 |
| container_title | Journal of dermatological science |
| container_volume | 82 |
| creator | Hiraoka, Chihiro Toki, Fujio Shiraishi, Ken Sayama, Koji Nishimura, Emi K Miura, Hiromasa Higashiyama, Shigeki Nanba, Daisuke |
| description | Highlights • Human dermal fibroblasts were clonally expanded with hypoxic culture without chromosomal aberration. • Comprehensive phenotypic and gene expression profiling revealed heterogeneity among individual fibroblast clones. • Human dermal fibroblasts were categorized into at least two functional clonal types by phenotypic and gene expression profiling. • Heterogeneity of dermal fibroblasts was accelerated with physiological aging. |
| doi_str_mv | 10.1016/j.jdermsci.2016.01.009 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1783912667</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0923181116300093</els_id><sourcerecordid>1783912667</sourcerecordid><originalsourceid>FETCH-LOGICAL-c531t-4d82028d9abd109345bf2ec0cd48efa8f34133324e1adf1212b6dbbd5b1cb9533</originalsourceid><addsrcrecordid>eNqFkUtv1DAUhS0EotPCX6i8ZJPgR5KJNwhU8ahUiQVFYmf5cU2dOvFgO1Tz73E0LQs2rK4sn3Mf30HokpKWEjq8ndrJQpqz8S2r75bQlhDxDO3ouOdNP4gfz9GOCMYbOlJ6hs5zngghPevES3TGhnHYi17sULl9iNiEuKiAy_EAGUeH79ZZLTjf-wU7r1PUQeWS8YMvd9h65yDBUvAhllq8Chm7mPAhxeDrlyo-LlgtFhef8wo4wRwtBL_8xEr74MvxFXrhqg1eP9YL9P3Tx9urL83N18_XVx9uGtNzWprOjoyw0QqlLSWCd712DAwxthvBqdHxjnLOWQdUWUcZZXqwWtteU6NFz_kFenPqW3f7tUIucvbZQAhqgbhmSfcjF5QNw75Kh5PUpJhzAicPyc8qHSUlciMuJ_lEXG7EJaGyEq_Gy8cZq57B_rU9Ia6C9ycB1Et_e0iytoDFgPUJTJE2-v_PePdPC1NxeqPCPRwhT3FNNb96j8xMEvlty32LnQ6cbH7-B2i-raI</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1783912667</pqid></control><display><type>article</type><title>Two clonal types of human skin fibroblasts with different potentials for proliferation and tissue remodeling ability</title><source>Elsevier ScienceDirect Journals Complete - AutoHoldings</source><source>MEDLINE</source><creator>Hiraoka, Chihiro ; Toki, Fujio ; Shiraishi, Ken ; Sayama, Koji ; Nishimura, Emi K ; Miura, Hiromasa ; Higashiyama, Shigeki ; Nanba, Daisuke</creator><creatorcontrib>Hiraoka, Chihiro ; Toki, Fujio ; Shiraishi, Ken ; Sayama, Koji ; Nishimura, Emi K ; Miura, Hiromasa ; Higashiyama, Shigeki ; Nanba, Daisuke</creatorcontrib><description>Highlights • Human dermal fibroblasts were clonally expanded with hypoxic culture without chromosomal aberration. • Comprehensive phenotypic and gene expression profiling revealed heterogeneity among individual fibroblast clones. • Human dermal fibroblasts were categorized into at least two functional clonal types by phenotypic and gene expression profiling. • Heterogeneity of dermal fibroblasts was accelerated with physiological aging.</description><identifier>ISSN: 0923-1811</identifier><identifier>EISSN: 1873-569X</identifier><identifier>DOI: 10.1016/j.jdermsci.2016.01.009</identifier><identifier>PMID: 26867959</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Aged ; Aged, 80 and over ; Cell Proliferation - physiology ; Cells, Cultured ; Child ; Child, Preschool ; Clone Cells - physiology ; Collagen - metabolism ; Collagen - physiology ; Dermal fibroblasts ; Dermatology ; Female ; Fibroblasts - metabolism ; Fibroblasts - physiology ; Fibrosis ; Gene Expression Profiling ; Heterogeneity ; Humans ; Hypoxia ; Infant ; Male ; Middle Aged ; Single cell cloning ; Skin - cytology ; Skin Aging - physiology ; Wound Healing - physiology</subject><ispartof>Journal of dermatological science, 2016-05, Vol.82 (2), p.84-94</ispartof><rights>Elsevier Ireland Ltd</rights><rights>2016 Elsevier Ireland Ltd</rights><rights>Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c531t-4d82028d9abd109345bf2ec0cd48efa8f34133324e1adf1212b6dbbd5b1cb9533</citedby><cites>FETCH-LOGICAL-c531t-4d82028d9abd109345bf2ec0cd48efa8f34133324e1adf1212b6dbbd5b1cb9533</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.jdermsci.2016.01.009$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,778,782,3539,27907,27908,45978</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26867959$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hiraoka, Chihiro</creatorcontrib><creatorcontrib>Toki, Fujio</creatorcontrib><creatorcontrib>Shiraishi, Ken</creatorcontrib><creatorcontrib>Sayama, Koji</creatorcontrib><creatorcontrib>Nishimura, Emi K</creatorcontrib><creatorcontrib>Miura, Hiromasa</creatorcontrib><creatorcontrib>Higashiyama, Shigeki</creatorcontrib><creatorcontrib>Nanba, Daisuke</creatorcontrib><title>Two clonal types of human skin fibroblasts with different potentials for proliferation and tissue remodeling ability</title><title>Journal of dermatological science</title><addtitle>J Dermatol Sci</addtitle><description>Highlights • Human dermal fibroblasts were clonally expanded with hypoxic culture without chromosomal aberration. • Comprehensive phenotypic and gene expression profiling revealed heterogeneity among individual fibroblast clones. • Human dermal fibroblasts were categorized into at least two functional clonal types by phenotypic and gene expression profiling. • Heterogeneity of dermal fibroblasts was accelerated with physiological aging.</description><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Cell Proliferation - physiology</subject><subject>Cells, Cultured</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Clone Cells - physiology</subject><subject>Collagen - metabolism</subject><subject>Collagen - physiology</subject><subject>Dermal fibroblasts</subject><subject>Dermatology</subject><subject>Female</subject><subject>Fibroblasts - metabolism</subject><subject>Fibroblasts - physiology</subject><subject>Fibrosis</subject><subject>Gene Expression Profiling</subject><subject>Heterogeneity</subject><subject>Humans</subject><subject>Hypoxia</subject><subject>Infant</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Single cell cloning</subject><subject>Skin - cytology</subject><subject>Skin Aging - physiology</subject><subject>Wound Healing - physiology</subject><issn>0923-1811</issn><issn>1873-569X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkUtv1DAUhS0EotPCX6i8ZJPgR5KJNwhU8ahUiQVFYmf5cU2dOvFgO1Tz73E0LQs2rK4sn3Mf30HokpKWEjq8ndrJQpqz8S2r75bQlhDxDO3ouOdNP4gfz9GOCMYbOlJ6hs5zngghPevES3TGhnHYi17sULl9iNiEuKiAy_EAGUeH79ZZLTjf-wU7r1PUQeWS8YMvd9h65yDBUvAhllq8Chm7mPAhxeDrlyo-LlgtFhef8wo4wRwtBL_8xEr74MvxFXrhqg1eP9YL9P3Tx9urL83N18_XVx9uGtNzWprOjoyw0QqlLSWCd712DAwxthvBqdHxjnLOWQdUWUcZZXqwWtteU6NFz_kFenPqW3f7tUIucvbZQAhqgbhmSfcjF5QNw75Kh5PUpJhzAicPyc8qHSUlciMuJ_lEXG7EJaGyEq_Gy8cZq57B_rU9Ia6C9ycB1Et_e0iytoDFgPUJTJE2-v_PePdPC1NxeqPCPRwhT3FNNb96j8xMEvlty32LnQ6cbH7-B2i-raI</recordid><startdate>20160501</startdate><enddate>20160501</enddate><creator>Hiraoka, Chihiro</creator><creator>Toki, Fujio</creator><creator>Shiraishi, Ken</creator><creator>Sayama, Koji</creator><creator>Nishimura, Emi K</creator><creator>Miura, Hiromasa</creator><creator>Higashiyama, Shigeki</creator><creator>Nanba, Daisuke</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20160501</creationdate><title>Two clonal types of human skin fibroblasts with different potentials for proliferation and tissue remodeling ability</title><author>Hiraoka, Chihiro ; Toki, Fujio ; Shiraishi, Ken ; Sayama, Koji ; Nishimura, Emi K ; Miura, Hiromasa ; Higashiyama, Shigeki ; Nanba, Daisuke</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c531t-4d82028d9abd109345bf2ec0cd48efa8f34133324e1adf1212b6dbbd5b1cb9533</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Cell Proliferation - physiology</topic><topic>Cells, Cultured</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Clone Cells - physiology</topic><topic>Collagen - metabolism</topic><topic>Collagen - physiology</topic><topic>Dermal fibroblasts</topic><topic>Dermatology</topic><topic>Female</topic><topic>Fibroblasts - metabolism</topic><topic>Fibroblasts - physiology</topic><topic>Fibrosis</topic><topic>Gene Expression Profiling</topic><topic>Heterogeneity</topic><topic>Humans</topic><topic>Hypoxia</topic><topic>Infant</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Single cell cloning</topic><topic>Skin - cytology</topic><topic>Skin Aging - physiology</topic><topic>Wound Healing - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hiraoka, Chihiro</creatorcontrib><creatorcontrib>Toki, Fujio</creatorcontrib><creatorcontrib>Shiraishi, Ken</creatorcontrib><creatorcontrib>Sayama, Koji</creatorcontrib><creatorcontrib>Nishimura, Emi K</creatorcontrib><creatorcontrib>Miura, Hiromasa</creatorcontrib><creatorcontrib>Higashiyama, Shigeki</creatorcontrib><creatorcontrib>Nanba, Daisuke</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of dermatological science</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hiraoka, Chihiro</au><au>Toki, Fujio</au><au>Shiraishi, Ken</au><au>Sayama, Koji</au><au>Nishimura, Emi K</au><au>Miura, Hiromasa</au><au>Higashiyama, Shigeki</au><au>Nanba, Daisuke</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Two clonal types of human skin fibroblasts with different potentials for proliferation and tissue remodeling ability</atitle><jtitle>Journal of dermatological science</jtitle><addtitle>J Dermatol Sci</addtitle><date>2016-05-01</date><risdate>2016</risdate><volume>82</volume><issue>2</issue><spage>84</spage><epage>94</epage><pages>84-94</pages><issn>0923-1811</issn><eissn>1873-569X</eissn><abstract>Highlights • Human dermal fibroblasts were clonally expanded with hypoxic culture without chromosomal aberration. • Comprehensive phenotypic and gene expression profiling revealed heterogeneity among individual fibroblast clones. • Human dermal fibroblasts were categorized into at least two functional clonal types by phenotypic and gene expression profiling. • Heterogeneity of dermal fibroblasts was accelerated with physiological aging.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>26867959</pmid><doi>10.1016/j.jdermsci.2016.01.009</doi><tpages>11</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0923-1811 |
| ispartof | Journal of dermatological science, 2016-05, Vol.82 (2), p.84-94 |
| issn | 0923-1811 1873-569X |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1783912667 |
| source | Elsevier ScienceDirect Journals Complete - AutoHoldings; MEDLINE |
| subjects | Aged Aged, 80 and over Cell Proliferation - physiology Cells, Cultured Child Child, Preschool Clone Cells - physiology Collagen - metabolism Collagen - physiology Dermal fibroblasts Dermatology Female Fibroblasts - metabolism Fibroblasts - physiology Fibrosis Gene Expression Profiling Heterogeneity Humans Hypoxia Infant Male Middle Aged Single cell cloning Skin - cytology Skin Aging - physiology Wound Healing - physiology |
| title | Two clonal types of human skin fibroblasts with different potentials for proliferation and tissue remodeling ability |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-16T11%3A39%3A33IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Two%20clonal%20types%20of%20human%20skin%20fibroblasts%20with%20different%20potentials%20for%20proliferation%20and%20tissue%20remodeling%20ability&rft.jtitle=Journal%20of%20dermatological%20science&rft.au=Hiraoka,%20Chihiro&rft.date=2016-05-01&rft.volume=82&rft.issue=2&rft.spage=84&rft.epage=94&rft.pages=84-94&rft.issn=0923-1811&rft.eissn=1873-569X&rft_id=info:doi/10.1016/j.jdermsci.2016.01.009&rft_dat=%3Cproquest_cross%3E1783912667%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1783912667&rft_id=info:pmid/26867959&rft_els_id=S0923181116300093&rfr_iscdi=true |