Two clonal types of human skin fibroblasts with different potentials for proliferation and tissue remodeling ability

Highlights • Human dermal fibroblasts were clonally expanded with hypoxic culture without chromosomal aberration. • Comprehensive phenotypic and gene expression profiling revealed heterogeneity among individual fibroblast clones. • Human dermal fibroblasts were categorized into at least two function...

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Veröffentlicht in:	Journal of dermatological science 2016-05, Vol.82 (2), p.84-94
Hauptverfasser:	Hiraoka, Chihiro, Toki, Fujio, Shiraishi, Ken, Sayama, Koji, Nishimura, Emi K, Miura, Hiromasa, Higashiyama, Shigeki, Nanba, Daisuke
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Aged, 80 and over Cell Proliferation - physiology Cells, Cultured Child Child, Preschool Clone Cells - physiology Collagen - metabolism Collagen - physiology Dermal fibroblasts Dermatology Female Fibroblasts - metabolism Fibroblasts - physiology Fibrosis Gene Expression Profiling Heterogeneity Humans Hypoxia Infant Male Middle Aged Single cell cloning Skin - cytology Skin Aging - physiology Wound Healing - physiology
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Zusammenfassung:	Highlights • Human dermal fibroblasts were clonally expanded with hypoxic culture without chromosomal aberration. • Comprehensive phenotypic and gene expression profiling revealed heterogeneity among individual fibroblast clones. • Human dermal fibroblasts were categorized into at least two functional clonal types by phenotypic and gene expression profiling. • Heterogeneity of dermal fibroblasts was accelerated with physiological aging.
ISSN:	0923-1811 1873-569X
DOI:	10.1016/j.jdermsci.2016.01.009