Efficacy analysis of sequential treatment with chemotherapy, ATRA and As(2)O(3) for acute promyelocytic leukemia
To investigate the efficacy and treatment outcome of different induction regimens, and different post-remission therapies for adult acute promyelocytic leukemia (APL). The outcome of 73 patients with newly diagnosed APL were retrospectively analyzed. According to the induction regimens, the patients...
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| Veröffentlicht in: | Zhōnghuá xuèyèxué zázhì 2010-05, Vol.31 (5), p.328-332 |
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| container_title | Zhōnghuá xuèyèxué zázhì |
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| creator | Ma, Xiang-Juan Ren, Han-Yun Cen, Xi-Nan Qiu, Zhi-Xiang Wang, Wen-Sheng Ou, Jin-Ping Wang, Ying Xu, Wei-Lin Li, Yuan Wang, Mang-Ju Wang, Li-Hong Dong, Yu-Jun Yin, Yue Liang, Ze-Yin |
| description | To investigate the efficacy and treatment outcome of different induction regimens, and different post-remission therapies for adult acute promyelocytic leukemia (APL).
The outcome of 73 patients with newly diagnosed APL were retrospectively analyzed. According to the induction regimens, the patients were divided into three groups: chemotherapy-only (14 cases group I), all-trans retinoic acid (ATRA) or combined with chemotherapy (33 cases group II), and ATRA combined with arsenic trioxide (As(2)O(3)) (26 cases group III). The complete remission (CR) rate and the time to CR (TTC) were analyzed. After CR, the patients were divided into 2 groups for post-remission therapies: one with sequential treatment of chemotherapy/ATRA/As(2)O(3) and the other with alternative treatment of chemotherapy/ATRA. The overall survival (OS), disease free survival (DFS) and relapse rate were compared between these two groups. Patients induced CR with both ATRA and As(2)O(3), and then sequentially treated with chemotherapy/ATRA/As(2) |
| format | Article |
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The outcome of 73 patients with newly diagnosed APL were retrospectively analyzed. According to the induction regimens, the patients were divided into three groups: chemotherapy-only (14 cases group I), all-trans retinoic acid (ATRA) or combined with chemotherapy (33 cases group II), and ATRA combined with arsenic trioxide (As(2)O(3)) (26 cases group III). The complete remission (CR) rate and the time to CR (TTC) were analyzed. After CR, the patients were divided into 2 groups for post-remission therapies: one with sequential treatment of chemotherapy/ATRA/As(2)O(3) and the other with alternative treatment of chemotherapy/ATRA. The overall survival (OS), disease free survival (DFS) and relapse rate were compared between these two groups. Patients induced CR with both ATRA and As(2)O(3), and then sequentially treated with chemotherapy/ATRA/As(2)</description><subject>Antineoplastic Combined Chemotherapy Protocols - therapeutic use</subject><subject>Disease-Free Survival</subject><subject>Humans</subject><subject>Leukemia, Promyelocytic, Acute - drug therapy</subject><subject>Remission Induction</subject><subject>Tretinoin - therapeutic use</subject><issn>0253-2727</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo1UM1qwzAY82FjLV1fYfjYwgK2v9pJjqF0P1AojO4cHOczNbObLHYYefsF1p2EQBKS7siSCQmZyEW-IOsYXcMkB1UAsAeyEJwLARyWpD9Y64w2E9VX7afoIu0sjfg94jU57WkaUKcwE_rj0oWaC4YuXXDQ_fRMq_NHNRtbWsWN2J42sKW2G6g2Y0LaD12Y0HdmSs5Qj-MXBqcfyb3VPuL6hivy-XI479-y4-n1fV8ds54LlbKSt2VjdhJ4sROKAQPkbSEawZnlXPFSomlLJbmV8xBkRSvzHBsFZleAaiysyOYvd64xj4mpDi4a9F5fsRtjzfMCSlaWALP06SYdm4Bt3Q8u6GGq_1-CX6UFYi0</recordid><startdate>201005</startdate><enddate>201005</enddate><creator>Ma, Xiang-Juan</creator><creator>Ren, Han-Yun</creator><creator>Cen, Xi-Nan</creator><creator>Qiu, Zhi-Xiang</creator><creator>Wang, Wen-Sheng</creator><creator>Ou, Jin-Ping</creator><creator>Wang, Ying</creator><creator>Xu, Wei-Lin</creator><creator>Li, Yuan</creator><creator>Wang, Mang-Ju</creator><creator>Wang, Li-Hong</creator><creator>Dong, Yu-Jun</creator><creator>Yin, Yue</creator><creator>Liang, Ze-Yin</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>201005</creationdate><title>Efficacy analysis of sequential treatment with chemotherapy, ATRA and As(2)O(3) for acute promyelocytic leukemia</title><author>Ma, Xiang-Juan ; Ren, Han-Yun ; Cen, Xi-Nan ; Qiu, Zhi-Xiang ; Wang, Wen-Sheng ; Ou, Jin-Ping ; Wang, Ying ; Xu, Wei-Lin ; Li, Yuan ; Wang, Mang-Ju ; Wang, Li-Hong ; Dong, Yu-Jun ; Yin, Yue ; Liang, Ze-Yin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p126t-91d9bc453184260303e1d82b210f116195ecd9651f5231e08d577eb63c4836bf3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>chi</language><creationdate>2010</creationdate><topic>Antineoplastic Combined Chemotherapy Protocols - therapeutic use</topic><topic>Disease-Free Survival</topic><topic>Humans</topic><topic>Leukemia, Promyelocytic, Acute - drug therapy</topic><topic>Remission Induction</topic><topic>Tretinoin - therapeutic use</topic><toplevel>online_resources</toplevel><creatorcontrib>Ma, Xiang-Juan</creatorcontrib><creatorcontrib>Ren, Han-Yun</creatorcontrib><creatorcontrib>Cen, Xi-Nan</creatorcontrib><creatorcontrib>Qiu, Zhi-Xiang</creatorcontrib><creatorcontrib>Wang, Wen-Sheng</creatorcontrib><creatorcontrib>Ou, Jin-Ping</creatorcontrib><creatorcontrib>Wang, Ying</creatorcontrib><creatorcontrib>Xu, Wei-Lin</creatorcontrib><creatorcontrib>Li, Yuan</creatorcontrib><creatorcontrib>Wang, Mang-Ju</creatorcontrib><creatorcontrib>Wang, Li-Hong</creatorcontrib><creatorcontrib>Dong, Yu-Jun</creatorcontrib><creatorcontrib>Yin, Yue</creatorcontrib><creatorcontrib>Liang, Ze-Yin</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Zhōnghuá xuèyèxué zázhì</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ma, Xiang-Juan</au><au>Ren, Han-Yun</au><au>Cen, Xi-Nan</au><au>Qiu, Zhi-Xiang</au><au>Wang, Wen-Sheng</au><au>Ou, Jin-Ping</au><au>Wang, Ying</au><au>Xu, Wei-Lin</au><au>Li, Yuan</au><au>Wang, Mang-Ju</au><au>Wang, Li-Hong</au><au>Dong, Yu-Jun</au><au>Yin, Yue</au><au>Liang, Ze-Yin</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Efficacy analysis of sequential treatment with chemotherapy, ATRA and As(2)O(3) for acute promyelocytic leukemia</atitle><jtitle>Zhōnghuá xuèyèxué zázhì</jtitle><addtitle>Zhonghua Xue Ye Xue Za Zhi</addtitle><date>2010-05</date><risdate>2010</risdate><volume>31</volume><issue>5</issue><spage>328</spage><epage>332</epage><pages>328-332</pages><issn>0253-2727</issn><abstract>To investigate the efficacy and treatment outcome of different induction regimens, and different post-remission therapies for adult acute promyelocytic leukemia (APL).
The outcome of 73 patients with newly diagnosed APL were retrospectively analyzed. According to the induction regimens, the patients were divided into three groups: chemotherapy-only (14 cases group I), all-trans retinoic acid (ATRA) or combined with chemotherapy (33 cases group II), and ATRA combined with arsenic trioxide (As(2)O(3)) (26 cases group III). The complete remission (CR) rate and the time to CR (TTC) were analyzed. After CR, the patients were divided into 2 groups for post-remission therapies: one with sequential treatment of chemotherapy/ATRA/As(2)O(3) and the other with alternative treatment of chemotherapy/ATRA. The overall survival (OS), disease free survival (DFS) and relapse rate were compared between these two groups. Patients induced CR with both ATRA and As(2)O(3), and then sequentially treated with chemotherapy/ATRA/As(2)</abstract><cop>China</cop><pmid>21122313</pmid><tpages>5</tpages></addata></record> |
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| ispartof | Zhōnghuá xuèyèxué zázhì, 2010-05, Vol.31 (5), p.328-332 |
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| language | chi |
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| source | MEDLINE; EZB-FREE-00999 freely available EZB journals |
| subjects | Antineoplastic Combined Chemotherapy Protocols - therapeutic use Disease-Free Survival Humans Leukemia, Promyelocytic, Acute - drug therapy Remission Induction Tretinoin - therapeutic use |
| title | Efficacy analysis of sequential treatment with chemotherapy, ATRA and As(2)O(3) for acute promyelocytic leukemia |
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