The prevalence of the Staphylococcus aureus tst gene among community- and hospital-acquired strains and isolates from Wegener’s Granulomatosis patients

To allow rapid identification of toxic shock syndrome toxin-1 (TSST-1)-producing Staphylococcus aureus strains, a real-time PCR assay for the detection of the tst gene, which encodes TSST-1, was developed. The assay was applied to S. aureus isolates from patients with Wegener’s Granulomatosis (WG),...

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Veröffentlicht in:FEMS microbiology letters 2005-04, Vol.245 (1), p.185-189
Hauptverfasser: Deurenberg, Ruud H., Nieuwenhuis, Rutger F., Driessen, Christel, London, Nancy, Stassen, Frank R., van Tiel, Frank H., Stobberingh, Ellen E., Vink, Cornelis
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Sprache:eng
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Zusammenfassung:To allow rapid identification of toxic shock syndrome toxin-1 (TSST-1)-producing Staphylococcus aureus strains, a real-time PCR assay for the detection of the tst gene, which encodes TSST-1, was developed. The assay was applied to S. aureus isolates from patients with Wegener’s Granulomatosis (WG), as well as isolates that were classified as either community- (CA) or hospital-acquired (HA). No significant difference in the percentage of tst-positive strains was observed between isolates from WG patients and CA isolates (24% and 25%, respectively). In contrast, only 14% of the HA isolates were tst-positive ( p < 0.05). Investigation of the clonal relationship between tst-positive CA and HA strains could indicated the recent emergence of a virulent S. aureus clone in the community.
ISSN:0378-1097
1574-6968
DOI:10.1016/j.femsle.2005.03.002