Blasticidin A as an Inhibitor of Aflatoxin Production by Aspergillus parasiticus

Blasticidin A, an antibiotic, showed strong inhibitory activity toward aflatoxin production by Aspergillus parasiticus. Its structure was characterized by NMR and chemical degradation experiments as 1, which is a tetramic acid derivative with a highly oxygenated long alkyl chain similar to aflastati...

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Veröffentlicht in:	Journal of antibiotics 2000/11/25, Vol.53(11), pp.1265-1271
Hauptverfasser:	SAKUDA, SHOHEI, ONO, MAKOTO, IKEDA, HIROYUKI, NAKAMURA, TAKEFUMI, INAGAKI, YASUHITO, KAWACHI, RYU, NAKAYAMA, JIRO, SUZUKI, AKINORI, ISOGAI, AKIRA, NAGASAWA, HIROMICHI
Format:	Artikel
Sprache:	eng
Schlagworte:	Aflastatin A Aflatoxins - antagonists & inhibitors Aflatoxins - biosynthesis Anti-Bacterial Agents - chemistry Anti-Bacterial Agents - pharmacology Antibiotics, microbial producers, chemotherapic agents, antiseptics, disinfecting agents Applied microbiology Aspergillus - drug effects Aspergillus - metabolism Aspergillus parasiticus Biological and medical sciences Blasticidin A Chemotherapic agents Fundamental and applied biological sciences. Psychology Microbiology Molecular Structure Pyrrolidinones - chemistry Pyrrolidinones - pharmacology Spectrum Analysis
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Beschreibung
Zusammenfassung:	Blasticidin A, an antibiotic, showed strong inhibitory activity toward aflatoxin production by Aspergillus parasiticus. Its structure was characterized by NMR and chemical degradation experiments as 1, which is a tetramic acid derivative with a highly oxygenated long alkyl chain similar to aflastatin A (2). Absolute configurations of the eight chiral centers at C-4, 6, 31, 32, 33, 34, 35 and 37 of 1 were chemically determined. Blasticidin A almost completely inhibited aflatoxin production at 0.5 μM.
ISSN:	0021-8820 1881-1469
DOI:	10.7164/antibiotics.53.1265