Time-course analysis of 3-epi-25-hydroxyvitamin D3 shows markedly elevated levels in early life, particularly from vitamin D supplementation in preterm infants

Background: An epimeric form of 25-hydroxyvitamin D 3 (25(OH)D 3 ) has recently been detected in clinical samples, with relatively high levels in infants. Little is known on 3-epi-25(OH)D 3 formation and physiological function. Our objective was to study dynamics of 3-epi-25(OH)D 3 formation during...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Pediatric research 2016-04, Vol.79 (4), p.647-653
Hauptverfasser:	Ooms, Nina, van Daal, Henny, Beijers, Antonius M., Gerrits, G. Peter J.M., Semmekrot, Ben A., van den Ouweland, Johannes M.W.
Format:	Artikel
Sprache:	eng
Schlagworte:	631/45/776 692/499 692/699/2743 Calcifediol - metabolism Dietary supplements Female Humans Infant Infant, Newborn Infant, Premature Male Medicine Medicine & Public Health Nutrition research Pediatric Surgery Pediatrics Premature birth translational-investigation Vitamin D Vitamin D - administration & dosage Vitamin deficiency
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Background: An epimeric form of 25-hydroxyvitamin D 3 (25(OH)D 3 ) has recently been detected in clinical samples, with relatively high levels in infants. Little is known on 3-epi-25(OH)D 3 formation and physiological function. Our objective was to study dynamics of 3-epi-25(OH)D 3 formation during infancy. Methods: 25(OH)D 3 and 3-epi-25(OH)D 3 levels were measured by liquid chromatography-tandem mass spectrometry in 22 preterm (aged 34–37 wk), 15 early preterm (aged
ISSN:	0031-3998 1530-0447
DOI:	10.1038/pr.2015.251