Shortening of hippocampal spin-spin relaxation time in probable Alzheimer's disease: a super(1)H magnetic resonance spectroscopy study

Shortening of hippocampal spin-spin relaxation time in probable Alzheimer's disease: a super(1)H magnetic resonance spectroscopy study

We quantified the differential effects of the spin-spin relaxation times (T sub(2)) of tissue water and cerebral spinal fluid in order to examine hippocampal T sub(2) changes as a non-invasive biomarker of Alzheimer's disease (AD). We measured T sub(2) in the right hippocampus of ten patients f...

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Veröffentlicht in:Neuroscience letters 2004-05, Vol.362 (3), p.167-170
Hauptverfasser: Haley, AP, Knight-Scott, J, Fuchs, K L, Simnad, VI, Manning, CA
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Sprache:eng
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Zusammenfassung:We quantified the differential effects of the spin-spin relaxation times (T sub(2)) of tissue water and cerebral spinal fluid in order to examine hippocampal T sub(2) changes as a non-invasive biomarker of Alzheimer's disease (AD). We measured T sub(2) in the right hippocampus of ten patients fulfilling the NINCDS-ADRDA criteria for AD and 40 healthy adult volunteers using localized proton magnetic resonance spectroscopy. The T sub(2) values of AD patients (73 plus or minus 8 ms) were significantly shorter (P
ISSN:0304-3940
DOI:10.1016/j.neulet.2004.01.031