Effect of caspofungin and micafungin in combination with farnesol against Candida parapsilosis biofilms

Highlights • The interaction of farnesol and echinocandins against Candida parapsilosis biofilms was studied. • FICIs, two methods based on Bliss independence, and time–kill experiments were used. • Farnesol showed synergism with echinocandins against C. parapsilosis biofilms. • Based on time–kill r...

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Veröffentlicht in:	International journal of antimicrobial agents 2016-04, Vol.47 (4), p.304-310
Hauptverfasser:	Kovács, Renátó, Bozó, Aliz, Gesztelyi, Rudolf, Domán, Marianna, Kardos, Gábor, Nagy, Fruzsina, Tóth, Zoltán, Majoros, László
Format:	Artikel
Sprache:	eng
Schlagworte:	Antifungal Agents - pharmacology Biofilms - drug effects Biofilms - growth & development Candida - classification Candida - drug effects Candida - growth & development Candida - physiology Candidemia - microbiology Colorimetry Drug interaction Drug Interactions Echinocandin Echinocandins - pharmacology Farnesol - pharmacology FICI Formazans - analysis Fractional inhibitory concentration index Humans Infectious Disease Lipopeptides - pharmacology Microbial Sensitivity Tests Non-linear regression Time–kill experiment
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Zusammenfassung:	Highlights • The interaction of farnesol and echinocandins against Candida parapsilosis biofilms was studied. • FICIs, two methods based on Bliss independence, and time–kill experiments were used. • Farnesol showed synergism with echinocandins against C. parapsilosis biofilms. • Based on time–kill results, caspofungin + farnesol was effective even at 24 h.
ISSN:	0924-8579 1872-7913
DOI:	10.1016/j.ijantimicag.2016.01.007