Cell-derived microvesicles mediate the delivery of miR-29a/c to suppress angiogenesis in gastric carcinoma

Highlights • Suppressed expression of miR-29a/c leads to the high levels of VEGF in the gastric tumor microenvironment. • miR-29a/c regulates VEGF expression by directly targeting the 3′UTR of VEGF mRNA. • Microvesicles secreted from HEK293T cells could be used as the nano-particles to pack and tran...

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Veröffentlicht in:	Cancer letters 2016-06, Vol.375 (2), p.331-339
Hauptverfasser:	Zhang, Haiyang, Bai, Ming, Deng, Ting, Liu, Rui, Wang, Xia, Qu, Yanjun, Duan, Jingjing, Zhang, Le, Ning, Tao, Ge, Shaohua, Li, Hongli, Zhou, Likun, Liu, Yuchen, Ying, Guoguang, Huang, Dingzhi, Ba, Yi
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiogenesis Animals Carcinoma - drug therapy Carcinoma - genetics Carcinoma - pathology Cell culture Cell growth Cell Line, Tumor Cell Proliferation - genetics Cell-Derived Microparticles - genetics Drug Delivery Systems Experiments Gastric cancer Gene expression Gene Expression Regulation, Neoplastic Hematology, Oncology and Palliative Medicine Humans Mice MicroRNAs - genetics Microvesicle miR-29 Neovascularization, Pathologic - genetics Neovascularization, Pathologic - therapy Proteins Stomach Neoplasms - drug therapy Stomach Neoplasms - genetics Stomach Neoplasms - pathology Transmission electron microscopy Tumor Microenvironment Vascular endothelial growth factor Vascular Endothelial Growth Factor A - biosynthesis Vascular Endothelial Growth Factor A - genetics VEGF Xenograft Model Antitumor Assays
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Zusammenfassung:	Highlights • Suppressed expression of miR-29a/c leads to the high levels of VEGF in the gastric tumor microenvironment. • miR-29a/c regulates VEGF expression by directly targeting the 3′UTR of VEGF mRNA. • Microvesicles secreted from HEK293T cells could be used as the nano-particles to pack and transport artificial selected miRNAs, regulating gene expression of targeted cells. • Microvesicle-packed miR-29a/c can be transported in vivo, suppressing angiogenesis in gastric cancer.
ISSN:	0304-3835 1872-7980
DOI:	10.1016/j.canlet.2016.03.026