One-Pot Synthesis of Benzothiazole-Tethered Chromanones/Coumarins via Claisen Rearrangement Using the Solid State Melt Reaction
A novel protocol has been successfully established for the efficient synthesis of benzothiazole-tethered chromanone/coumarin scaffolds via Claisen rearrangement using a solid state melt reaction in a one-pot manner. Benzothiazole formation and Claisen rearrangement involve the cleavage of S–S and C–...
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| Veröffentlicht in: | Journal of organic chemistry 2016-04, Vol.81 (8), p.3391-3399 |
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| Hauptverfasser: | , |
| Format: | Artikel |
| Sprache: | eng |
| Online-Zugang: | Volltext |
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| Zusammenfassung: | A novel protocol has been successfully established for the efficient synthesis of benzothiazole-tethered chromanone/coumarin scaffolds via Claisen rearrangement using a solid state melt reaction in a one-pot manner. Benzothiazole formation and Claisen rearrangement involve the cleavage of S–S and C–O bonds and formation of C–S, CN, and C–C bonds in a single operation without using a catalyst or solvent. |
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| ISSN: | 0022-3263 1520-6904 |
| DOI: | 10.1021/acs.joc.5b02920 |