Adverse Events, Including Death, Associated with the Use of 1,4-Butanediol

The industrial solvent 1,4-butanediol, when ingested, is rapidly converted to γ-hydroxybutyrate, a neuromodulator with depressant effects, primarily on the central nervous system. γ-Hydroxybutyrate is a metabolite of γ-aminobutyric acid (GABA), which is an inhibitory neurotransmitter (Figure 1). 1,4...

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