Adverse Events, Including Death, Associated with the Use of 1,4-Butanediol

The industrial solvent 1,4-butanediol, when ingested, is rapidly converted to γ-hydroxybutyrate, a neuromodulator with depressant effects, primarily on the central nervous system. γ-Hydroxybutyrate is a metabolite of γ-aminobutyric acid (GABA), which is an inhibitory neurotransmitter (Figure 1). 1,4...

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Veröffentlicht in:The New England journal of medicine 2001-01, Vol.344 (2), p.87-94
Hauptverfasser: Zvosec, Deborah L, Smith, Stephen W, McCutcheon, J. Rod, Spillane, Joe, Hall, Bradley J, Peacock, Elizabeth A
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Sprache:eng
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Zusammenfassung:The industrial solvent 1,4-butanediol, when ingested, is rapidly converted to γ-hydroxybutyrate, a neuromodulator with depressant effects, primarily on the central nervous system. γ-Hydroxybutyrate is a metabolite of γ-aminobutyric acid (GABA), which is an inhibitory neurotransmitter (Figure 1). 1,4-Butanediol and γ-hydroxybutyrate occur endogenously in humans in trace amounts. 1 γ-Hydroxybutyrate was marketed to bodybuilders in the 1980s as a purported aid to muscle building and fat loss. Because of its euphoric and sexual effects, it became a drug of abuse. Reports of the drug's toxicity resulted in warnings about health risks and a federal prohibition of the manufacture, sale, and use of . . .
ISSN:0028-4793
1533-4406
DOI:10.1056/NEJM200101113440202