Adverse Events, Including Death, Associated with the Use of 1,4-Butanediol
The industrial solvent 1,4-butanediol, when ingested, is rapidly converted to γ-hydroxybutyrate, a neuromodulator with depressant effects, primarily on the central nervous system. γ-Hydroxybutyrate is a metabolite of γ-aminobutyric acid (GABA), which is an inhibitory neurotransmitter (Figure 1). 1,4...
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Veröffentlicht in: | The New England journal of medicine 2001-01, Vol.344 (2), p.87-94 |
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Zusammenfassung: | The industrial solvent 1,4-butanediol, when ingested, is rapidly converted to γ-hydroxybutyrate, a neuromodulator with depressant effects, primarily on the central nervous system. γ-Hydroxybutyrate is a metabolite of γ-aminobutyric acid (GABA), which is an inhibitory neurotransmitter (Figure 1). 1,4-Butanediol and γ-hydroxybutyrate occur endogenously in humans in trace amounts.
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γ-Hydroxybutyrate was marketed to bodybuilders in the 1980s as a purported aid to muscle building and fat loss. Because of its euphoric and sexual effects, it became a drug of abuse. Reports of the drug's toxicity resulted in warnings about health risks and a federal prohibition of the manufacture, sale, and use of . . . |
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ISSN: | 0028-4793 1533-4406 |
DOI: | 10.1056/NEJM200101113440202 |