Cutting-Edge and Time-Honored Strategies for Stereoselective Construction of C–N Bonds in Total Synthesis

The main objective of this review is to provide a comprehensive survey of methods used for stereoselective construction of carbon–nitrogen bonds during the total synthesis of nitrogen-containing natural products that have appeared in the literature since 2000. The material is organized by specific r...

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Veröffentlicht in:	Chemical reviews 2016-04, Vol.116 (7), p.4441-4557
Hauptverfasser:	Mailyan, Artur K, Eickhoff, John A, Minakova, Anastasiia S, Gu, Zhenhua, Lu, Ping, Zakarian, Armen
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological Products - chemical synthesis Biological Products - chemistry Carbon Carbon - chemistry Chemical bonds Molecular Conformation Natural products Nitrogen Nitrogen - chemistry Stereoisomerism Time Factors
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Beschreibung
Zusammenfassung:	The main objective of this review is to provide a comprehensive survey of methods used for stereoselective construction of carbon–nitrogen bonds during the total synthesis of nitrogen-containing natural products that have appeared in the literature since 2000. The material is organized by specific reaction in order of decreasing number of applications in natural product synthesis. About 800 total syntheses of natural products with stereogenic carbon–nitrogen bonds described since 2000 have been reviewed.
ISSN:	0009-2665 1520-6890
DOI:	10.1021/acs.chemrev.5b00712