Additional pyrrolomycins from cultures of Streptomyces fumanus

Along with dioxapyrrolomycin (1), four new pyrrolomycin antibiotics, namely, pyrrolomycin G (3), pyrrolomycin H (4), pyrrolomycin I (5), and pyrrolomycin J (6), were produced in cultures of Streptomyces fumanus. Apart from dioxapyrrolomycin, pyrrolomycin G and pyrrolomycin H are the only other chira...

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Veröffentlicht in:	Journal of natural products (Washington, D.C.) D.C.), 2005-02, Vol.68 (2), p.277-279
Hauptverfasser:	Charan, R.D, Schlingmann, G, Bernan, V.S, Feng, X, Carter, G.T
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-Bacterial Agents - chemistry Anti-Bacterial Agents - classification Anti-Bacterial Agents - isolation & purification Anti-Bacterial Agents - pharmacology antibacterial properties antibiotics Antibiotics (antibacterial agents, antifungal agents) Antibiotics, microbial producers, chemotherapic agents, antiseptics, disinfecting agents Applied microbiology Biological and medical sciences chemical structure dioxapyrrolomycin Enterococcus faecium Escherichia coli Fundamental and applied biological sciences. Psychology Microbial Sensitivity Tests Microbiology Molecular Structure Nuclear Magnetic Resonance, Biomolecular pyrroles Pyrroles - chemistry Pyrroles - isolation & purification Pyrroles - pharmacology pyrrolomycins spectral analysis Staphylococcus aureus Streptomyces - chemistry Streptomyces fumanus
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Zusammenfassung:	Along with dioxapyrrolomycin (1), four new pyrrolomycin antibiotics, namely, pyrrolomycin G (3), pyrrolomycin H (4), pyrrolomycin I (5), and pyrrolomycin J (6), were produced in cultures of Streptomyces fumanus. Apart from dioxapyrrolomycin, pyrrolomycin G and pyrrolomycin H are the only other chiral members of the pyrrolomycin family of antibiotics, and their absolute stereochemistry was deduced to be 13S. Here, we report the isolation, structure elucidation, and antimicrobial activity of these new pyrrolomycins.
ISSN:	0163-3864 1520-6025
DOI:	10.1021/np0496542