Modulating Effect of Matrices with Calcium Phosphate Coating on Cytotoxicity of Strontium Ranelate and Ibandronic Acid In Vitro
Strontium ranelate (29 μg/ml) and ibandronic acid (50 μM) produced a cytotoxic effect on rat bone marrow myelokaryocytes in vitro . Strontium ranelate increased the number of myelokaryocytes with signs of necrosis, ibandronic acid increased the number of apoptotic and necrotic cells in the 9-day 2D...
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| Veröffentlicht in: | Bulletin of experimental biology and medicine 2014-06, Vol.157 (2), p.215-219 |
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| creator | Khlusov, I. A. Ryazantseva, N. V. Vengerovskii, A. I. Nechaev, K. A. Yakushina, V. D. Dvornichenko, M. V. Sharkeev, Yu. P. Legostayeva, E. V. Novitskii, V. V. |
| description | Strontium ranelate (29 μg/ml) and ibandronic acid (50 μM) produced a cytotoxic effect on rat bone marrow myelokaryocytes
in vitro
. Strontium ranelate increased the number of myelokaryocytes with signs of necrosis, ibandronic acid increased the number of apoptotic and necrotic cells in the 9-day 2D culture of bone marrow cells on the plastic surface of the wells of culture plates. Co-culturing of the bone marrow with 3D matrices with microarc calcium phosphate coating that simulated bone mineral matrix increased intracellular ROS concentration, but abolished the cytotoxic effect of these drugs. |
| doi_str_mv | 10.1007/s10517-014-2528-7 |
| format | Article |
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. Strontium ranelate increased the number of myelokaryocytes with signs of necrosis, ibandronic acid increased the number of apoptotic and necrotic cells in the 9-day 2D culture of bone marrow cells on the plastic surface of the wells of culture plates. Co-culturing of the bone marrow with 3D matrices with microarc calcium phosphate coating that simulated bone mineral matrix increased intracellular ROS concentration, but abolished the cytotoxic effect of these drugs.</description><identifier>ISSN: 0007-4888</identifier><identifier>EISSN: 1573-8221</identifier><identifier>DOI: 10.1007/s10517-014-2528-7</identifier><identifier>PMID: 24958373</identifier><identifier>CODEN: BEXBAN</identifier><language>eng</language><publisher>Boston: Springer US</publisher><subject>Animals ; Apoptosis ; Apoptosis - drug effects ; Biomedical and Life Sciences ; Biomedicine ; Bone Marrow - pathology ; Calcium phosphate ; Calcium Phosphates - chemistry ; Cell Biology ; Cells, Cultured ; Coatings ; Diphosphonates - pharmacology ; Flow Cytometry ; Internal Medicine ; Laboratory Medicine ; Necrosis - chemically induced ; Pathology ; Rats ; Strontium ; Thiophenes - pharmacology</subject><ispartof>Bulletin of experimental biology and medicine, 2014-06, Vol.157 (2), p.215-219</ispartof><rights>Springer Science+Business Media New York 2014</rights><rights>COPYRIGHT 2014 Springer</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c573t-27e754bdeabd6d531b997942f0a5e65b0b0bc67a6c0a48564b0ddaffd70104f13</citedby><cites>FETCH-LOGICAL-c573t-27e754bdeabd6d531b997942f0a5e65b0b0bc67a6c0a48564b0ddaffd70104f13</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10517-014-2528-7$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10517-014-2528-7$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27903,27904,41467,42536,51297</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24958373$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Khlusov, I. A.</creatorcontrib><creatorcontrib>Ryazantseva, N. V.</creatorcontrib><creatorcontrib>Vengerovskii, A. I.</creatorcontrib><creatorcontrib>Nechaev, K. A.</creatorcontrib><creatorcontrib>Yakushina, V. D.</creatorcontrib><creatorcontrib>Dvornichenko, M. V.</creatorcontrib><creatorcontrib>Sharkeev, Yu. P.</creatorcontrib><creatorcontrib>Legostayeva, E. V.</creatorcontrib><creatorcontrib>Novitskii, V. V.</creatorcontrib><title>Modulating Effect of Matrices with Calcium Phosphate Coating on Cytotoxicity of Strontium Ranelate and Ibandronic Acid In Vitro</title><title>Bulletin of experimental biology and medicine</title><addtitle>Bull Exp Biol Med</addtitle><addtitle>Bull Exp Biol Med</addtitle><description>Strontium ranelate (29 μg/ml) and ibandronic acid (50 μM) produced a cytotoxic effect on rat bone marrow myelokaryocytes
in vitro
. Strontium ranelate increased the number of myelokaryocytes with signs of necrosis, ibandronic acid increased the number of apoptotic and necrotic cells in the 9-day 2D culture of bone marrow cells on the plastic surface of the wells of culture plates. Co-culturing of the bone marrow with 3D matrices with microarc calcium phosphate coating that simulated bone mineral matrix increased intracellular ROS concentration, but abolished the cytotoxic effect of these drugs.</description><subject>Animals</subject><subject>Apoptosis</subject><subject>Apoptosis - drug effects</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Bone Marrow - pathology</subject><subject>Calcium phosphate</subject><subject>Calcium Phosphates - chemistry</subject><subject>Cell Biology</subject><subject>Cells, Cultured</subject><subject>Coatings</subject><subject>Diphosphonates - pharmacology</subject><subject>Flow Cytometry</subject><subject>Internal Medicine</subject><subject>Laboratory Medicine</subject><subject>Necrosis - chemically induced</subject><subject>Pathology</subject><subject>Rats</subject><subject>Strontium</subject><subject>Thiophenes - pharmacology</subject><issn>0007-4888</issn><issn>1573-8221</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNqNkl9r1TAYxoMo7jj9AN5IQBjedCZp06SXh7LpYEPx321I0-Q0o02OSYqeq311Uzp1EwUJJLx5f89DXvIA8ByjU4wQex0xopgVCFcFoYQX7AHYYMrKghOCH4INylBRcc6PwJMYr5cS1fgxOCJVQ3nJyg24ufL9PMpk3Q6eGaNVgt7AK5mCVTrCbzYNsJWjsvME3w8-7geZNGz9qvAOtofkk_9ulU2HRfoxBe_Sgn-QTo8LLV0PL7q8545VcKtsrh38YjP6FDwycoz62e15DD6fn31q3xaX795ctNvLQuV5UkGYZrTqei27vu5pibumYU1FDJJU17RDeamayVohWXFaVx3qe2lMzxBGlcHlMXi1-u6D_zrrmMRko9LjmB_p5ygw44gSivB_oLQipGGoKTP68g_02s_B5UGyIStJ2SDEf1M7OWphnfEpSLWYim3J8-9RRkmmTv9C5dXrySrvtLH5_p7g5I5g0HJMQ_TjnKx38T6IV1AFH2PQRuyDnWQ4CIzEEiSxBklkgViCJFjWvLidbO4m3f9S_ExOBsgKxNxyOx3ujP5P1x9mTNCs</recordid><startdate>20140601</startdate><enddate>20140601</enddate><creator>Khlusov, I. 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A. ; Ryazantseva, N. V. ; Vengerovskii, A. I. ; Nechaev, K. A. ; Yakushina, V. D. ; Dvornichenko, M. V. ; Sharkeev, Yu. P. ; Legostayeva, E. V. ; Novitskii, V. 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in vitro
. Strontium ranelate increased the number of myelokaryocytes with signs of necrosis, ibandronic acid increased the number of apoptotic and necrotic cells in the 9-day 2D culture of bone marrow cells on the plastic surface of the wells of culture plates. Co-culturing of the bone marrow with 3D matrices with microarc calcium phosphate coating that simulated bone mineral matrix increased intracellular ROS concentration, but abolished the cytotoxic effect of these drugs.</abstract><cop>Boston</cop><pub>Springer US</pub><pmid>24958373</pmid><doi>10.1007/s10517-014-2528-7</doi><tpages>5</tpages></addata></record> |
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| source | MEDLINE; Springer Nature - Complete Springer Journals |
| subjects | Animals Apoptosis Apoptosis - drug effects Biomedical and Life Sciences Biomedicine Bone Marrow - pathology Calcium phosphate Calcium Phosphates - chemistry Cell Biology Cells, Cultured Coatings Diphosphonates - pharmacology Flow Cytometry Internal Medicine Laboratory Medicine Necrosis - chemically induced Pathology Rats Strontium Thiophenes - pharmacology |
| title | Modulating Effect of Matrices with Calcium Phosphate Coating on Cytotoxicity of Strontium Ranelate and Ibandronic Acid In Vitro |
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