Modulating Effect of Matrices with Calcium Phosphate Coating on Cytotoxicity of Strontium Ranelate and Ibandronic Acid In Vitro

Strontium ranelate (29 μg/ml) and ibandronic acid (50 μM) produced a cytotoxic effect on rat bone marrow myelokaryocytes in vitro . Strontium ranelate increased the number of myelokaryocytes with signs of necrosis, ibandronic acid increased the number of apoptotic and necrotic cells in the 9-day 2D...

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Veröffentlicht in:	Bulletin of experimental biology and medicine 2014-06, Vol.157 (2), p.215-219
Hauptverfasser:	Khlusov, I. A., Ryazantseva, N. V., Vengerovskii, A. I., Nechaev, K. A., Yakushina, V. D., Dvornichenko, M. V., Sharkeev, Yu. P., Legostayeva, E. V., Novitskii, V. V.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis Apoptosis - drug effects Biomedical and Life Sciences Biomedicine Bone Marrow - pathology Calcium phosphate Calcium Phosphates - chemistry Cell Biology Cells, Cultured Coatings Diphosphonates - pharmacology Flow Cytometry Internal Medicine Laboratory Medicine Necrosis - chemically induced Pathology Rats Strontium Thiophenes - pharmacology
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Zusammenfassung:	Strontium ranelate (29 μg/ml) and ibandronic acid (50 μM) produced a cytotoxic effect on rat bone marrow myelokaryocytes in vitro . Strontium ranelate increased the number of myelokaryocytes with signs of necrosis, ibandronic acid increased the number of apoptotic and necrotic cells in the 9-day 2D culture of bone marrow cells on the plastic surface of the wells of culture plates. Co-culturing of the bone marrow with 3D matrices with microarc calcium phosphate coating that simulated bone mineral matrix increased intracellular ROS concentration, but abolished the cytotoxic effect of these drugs.
ISSN:	0007-4888 1573-8221
DOI:	10.1007/s10517-014-2528-7