Effect of Erythropoietin on Free Radical Oxidation and Glycoprotein Expression in Platelets under Conditions of Chronic Renal Failure

A short-term open prospective study examined 62 patients at the terminal stage of chronic renal failure. The experimental group received erythropoietin in a total dose of about 40,000 U. The expression of glycoproteins IIb-IIIa, IIb, and Ib was enhanced, the content of LPO products was elevated, and...

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Veröffentlicht in:	Bulletin of experimental biology and medicine 2014-05, Vol.157 (1), p.25-27
1. Verfasser:	Osikov, M. V.
Format:	Artikel
Sprache:	eng
Schlagworte:	Biomedical and Life Sciences Biomedicine Blood Platelets - drug effects Blood Platelets - metabolism Catalase - blood Cell Biology Chronic kidney failure Drug Administration Schedule Erythropoietin Erythropoietin - therapeutic use Female Free Radicals - antagonists & inhibitors Free Radicals - metabolism Gene Expression - drug effects Humans Internal Medicine Kidney - drug effects Kidney - metabolism Kidney - pathology Kidney Failure, Chronic - drug therapy Kidney Failure, Chronic - genetics Kidney Failure, Chronic - metabolism Kidney Failure, Chronic - pathology Laboratory Medicine Lipid Peroxidation - drug effects Male Middle Aged Oxidation-Reduction Oxidation-reduction reaction Pathology Platelet Glycoprotein GPIb-IX Complex - antagonists & inhibitors Platelet Glycoprotein GPIb-IX Complex - genetics Platelet Glycoprotein GPIb-IX Complex - metabolism Platelet Glycoprotein GPIIb-IIIa Complex - antagonists & inhibitors Platelet Glycoprotein GPIIb-IIIa Complex - genetics Platelet Glycoprotein GPIIb-IIIa Complex - metabolism Platelet Membrane Glycoprotein IIb - genetics Platelet Membrane Glycoprotein IIb - metabolism Prospective Studies Superoxide Dismutase - blood
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Zusammenfassung:	A short-term open prospective study examined 62 patients at the terminal stage of chronic renal failure. The experimental group received erythropoietin in a total dose of about 40,000 U. The expression of glycoproteins IIb-IIIa, IIb, and Ib was enhanced, the content of LPO products was elevated, and SOD and catalase activities were reduced in platelets from patients with chronic renal failure. Administration of erythropoietin partially restored free radical oxidation and expression of glycoproteins IIb-IIIa, IIb, and Ib in platelets. A significant correlation was revealed between the expression of platelet receptors on the one hand, and content of LPO products and SOD and catalase activities, on the other hand.
ISSN:	0007-4888 1573-8221
DOI:	10.1007/s10517-014-2483-3