Role of Neuropeptide Y in Myocardial Contractility of Rats during Early Postnatal Ontogeny

We studied the effect of neuropeptide Y in concentrations of 10 –10 -10 –6 M on myocardial contractility of rats at the age of 7, 21, and 100 days. Studying the isometric contraction of myocardial strips showed that neuropeptide Y decreases the force of myocardial contraction in 7-day-old rat pups....

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Bulletin of experimental biology and medicine 2014-08, Vol.157 (4), p.421-423
Hauptverfasser:	Zverev, A. A., Anikina, T. A., Maslyukov, P. M., rov, T. L. Zefi
Format:	Artikel
Sprache:	eng
Schlagworte:	Aging - physiology Animals Biomedical and Life Sciences Biomedicine Cell Biology Culture Media Electric Stimulation Heart - drug effects Internal Medicine Isometric Contraction - drug effects Laboratory Medicine Myocardial Contraction - drug effects Neuropeptide Y Neuropeptide Y - pharmacology Pathology Rats Tissue Culture Techniques
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	We studied the effect of neuropeptide Y in concentrations of 10 –10 -10 –6 M on myocardial contractility of rats at the age of 7, 21, and 100 days. Studying the isometric contraction of myocardial strips showed that neuropeptide Y decreases the force of myocardial contraction in 7-day-old rat pups. Exogenous neuropeptide Y produced a biphasic effect in 21-day-old rats, which was manifested in the increase and subsequent decrease in myocardial contractility. Neuropeptide Y had little effect on myocardial contractility of 100-day-old animals.
ISSN:	0007-4888 1573-8221
DOI:	10.1007/s10517-014-2581-2