Development of Endoplasmic Reticulum Stress during Experimental Oxalate Nephrolithiasis

Morphological and ultrastructural study of the kidney was performed in rats with oxalate nephrolithiasis. Specific features of endoplasmic reticulum stress were evaluated during nephrolithiasis and treatment with α-tocopherol. We observed the signs of endoplasmic reticulum stress with activation of...

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Veröffentlicht in:Bulletin of experimental biology and medicine 2016, Vol.160 (3), p.381-385
Hauptverfasser: Motin, Yu. G., Lepilov, A. V., Bgatova, N. P., Zharikov, A. Yu, Motina, N. V., Lapii, G. A., Lushnikova, E. L., Nepomnyashchikh, L. M.
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Sprache:eng
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Zusammenfassung:Morphological and ultrastructural study of the kidney was performed in rats with oxalate nephrolithiasis. Specific features of endoplasmic reticulum stress were evaluated during nephrolithiasis and treatment with α-tocopherol. We observed the signs of endoplasmic reticulum stress with activation of proapoptotic pathways and injury to the cell lining in nephron tubules and collecting ducts. Ultrastructural changes were found in the organelles, nuclei, and cell membranes of epitheliocytes. A relationship was revealed between endoplasmic reticulum stress and oxidative damage, which developed at the early state of lithogenesis.
ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-016-3176-x