Role of JNK and Contribution of p53 to the Realization of the Growth Potential of Mesenchymal Precursor Cells under the Effect of Fibroblast Growth Factor

The role of JNK-mediated signal pathway and participation of p53 transcription factor in stimulation of mesenchymal precursor cell function by the fibroblast growth factor was studied. The levels of fibroblast colony- and cluster formation and proliferative activity of mesenchymal precursors increas...

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Veröffentlicht in:	Bulletin of experimental biology and medicine 2015-08, Vol.159 (4), p.479-481
Hauptverfasser:	Zyuz’kov, G. N., Zhdanov, V. V., Udut, E. V., Miroshnichenko, L. A., Khrichkova, T. Yu, Danilets, M. G., Simanina, E. V., Chaikovskii, A. V., Agafonov, V. I., Sherstoboev, E. Yu, Minakova, M. Yu, Burmina, Ya. V., Udut, V. V., Dygai, A. M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biomedical and Life Sciences Biomedicine Cell Biology Cell Proliferation Cells, Cultured Cellular signal transduction Fibroblast growth factors Fibroblast Growth Factors - physiology Internal Medicine Laboratory Medicine Male MAP Kinase Kinase 4 - metabolism Mesenchymal Stromal Cells - physiology Mice, Inbred CBA Pathology Signal Transduction Stem cells Tumor proteins Tumor Suppressor Protein p53 - physiology
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Zusammenfassung:	The role of JNK-mediated signal pathway and participation of p53 transcription factor in stimulation of mesenchymal precursor cell function by the fibroblast growth factor was studied. The levels of fibroblast colony- and cluster formation and proliferative activity of mesenchymal precursors increased in response to JNK and p53 specific inhibitors. JNK and p53 blockers did not change the rate of fibroblast growth factor-induced progenitor element differentiation.
ISSN:	0007-4888 1573-8221
DOI:	10.1007/s10517-015-2997-3