Role of JNK and Contribution of p53 into Growth Potential of Mesenchymal Progenitor Cells In Vitro

Specifi c JNK and p53 inhibitors stimulated the formation of fi broblast colonies (CFU-F) and clusters (ClFU-F) and increased proliferative activity of mesenchymal progenitor cells. No effects of inhibitors of JNK and p53 on differentiation of progenitor elements were revealed.

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Bulletin of experimental biology and medicine 2015-06, Vol.159 (2), p.245-247
Hauptverfasser:	Zyuz’kov, G. N., Zhdanov, V. V., Udut, E. V., Miroshnichenko, L. A., Danilets, M. G., Simanina, E. V., Trofimova, E. S., Chaikovskii, A. V., Agafonov, V. I., Sherstoboev, E. Yu, Minakova, M. Yu, Burmina, Ya. V., Udut, V. V., Dygai, A. M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Benzothiazoles - pharmacology Biomedical and Life Sciences Biomedicine Cell Biology Cell Proliferation - drug effects Cell Proliferation - physiology Hydroxyurea In Vitro Techniques Internal Medicine Laboratory Medicine Male MAP Kinase Kinase 4 - antagonists & inhibitors Mesenchymal Stromal Cells - metabolism Mesenchymal Stromal Cells - physiology Mice Mice, Inbred CBA Pathology Protein Kinase Inhibitors - pharmacology Signal Transduction - physiology Statistics, Nonparametric Stem cells Toluene - analogs & derivatives Toluene - pharmacology Tumor proteins Tumor Suppressor Protein p53 - antagonists & inhibitors
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Specifi c JNK and p53 inhibitors stimulated the formation of fi broblast colonies (CFU-F) and clusters (ClFU-F) and increased proliferative activity of mesenchymal progenitor cells. No effects of inhibitors of JNK and p53 on differentiation of progenitor elements were revealed.
ISSN:	0007-4888 1573-8221
DOI:	10.1007/s10517-015-2933-6