The Use of Nanocomposite Coatings with Various Physicochemical Properties in Tissue Engineering

We studied the effect of nanocomposite coatings with various physicochemical properties on the structural and functional properties (adhesion potential, phenotype, gene expression) of mesenchymal stem cells. Of all tested nanocoatings (Al 2 O 3 , ZrO 2 , Ta 2 O 5 ), oxide coating Al 2 O 3 enriched i...

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Veröffentlicht in:	Bulletin of experimental biology and medicine 2013-12, Vol.156 (2), p.252-254
Hauptverfasser:	Gol’tsev, A. N., Rassokha, I. V., Dubrava, T. G., Ostankova, L. V., Ostankov, M. V., Gordienko, E. A., Safonov, V. I., Zykova, A. V.
Format:	Artikel
Sprache:	eng
Schlagworte:	Aluminum Oxide - pharmacology Animals Antigens, Differentiation - biosynthesis Biomedical and Life Sciences Biomedicine Bone Marrow Cells - drug effects Cell Adhesion - drug effects Cell Biology Cells, Cultured Coated Materials, Biocompatible - chemistry Coated Materials, Biocompatible - pharmacology Coatings Gene expression Gene Expression - drug effects Indoleamine-Pyrrole 2,3,-Dioxygenase - biosynthesis Internal Medicine Laboratory Medicine Materials Testing Mesenchymal Stem Cells - drug effects Mice Mice, Inbred CBA Nanocomposites - chemistry Nanotechnologies Nanotechnology Oxides - pharmacology Pathology Surface Properties Tantalum - pharmacology Tissue engineering Tissue Engineering - methods Zirconium - pharmacology
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Zusammenfassung:	We studied the effect of nanocomposite coatings with various physicochemical properties on the structural and functional properties (adhesion potential, phenotype, gene expression) of mesenchymal stem cells. Of all tested nanocoatings (Al 2 O 3 , ZrO 2 , Ta 2 O 5 ), oxide coating Al 2 O 3 enriched in vitro monolayer bone marrow cell culture with cells carrying mesenchymal stem cells phenotype markers and stimulated expression of ido gene, which can confer new therapeutic potencies to these cells and extend their application in clinical practice.
ISSN:	0007-4888 1573-8221
DOI:	10.1007/s10517-013-2324-9