Functional Activity of BK sub(Ca) Channels in Coronary Vascular Smooth Muscle Cells during Combined Exposure to Hyperglycemia and Stress

The effect of tetraethylammonium in a dose of 1 mM (inhibiting functional activity and preventing opening of BK sub(Ca) channels) was least pronounced during restraint stress. The influence of this agent was more significant in animals exposed to 14-day hyperglycemia alone or in combination with restraint stress. Therefore, hyperglycemia and stress (individual or combined exposure) significantly inhibit functional activity of BK sub(Ca) channels in smooth muscles of the coronary vessels. Our results suggest that the development of hyperglycemia is realized via pathogenetic mechanisms of vascular injury in the heart (similarly to stress conditions). Permanent increase in blood glucose level and 6-h immobilization probably induces nonspecific post-stress abnormalities in channel function.