Blood Microvesicles during Chronic Lymphoproliferative Diseases

The levels of CD19 + and CD20 + microvesicles were estimated in the blood of patients with B-cell chronic lymphocytic leukemia and indolent non-Hodgkin lymphoma by flow cytometry method. It was found that the number of B cell microvesicles is several times higher in patients than in volunteers. The...

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Veröffentlicht in:	Bulletin of experimental biology and medicine 2013-11, Vol.156 (1), p.94-97
Hauptverfasser:	Domnikova, N. P., Dolgikh, T. Yu, Sholenberg, E. V., Vorontsova, E. V., Goreva, O. B., Mel’nikova, E. V., Gorbachenko, E. A., Grishanova, A. Yu
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Antigens, CD19 - metabolism Antigens, CD20 - metabolism B-Lymphocytes - immunology B-Lymphocytes - metabolism Biomedical and Life Sciences Biomedicine Case-Control Studies Cell Biology Cell-Derived Microparticles - metabolism Female Humans Immunophenotyping Internal Medicine Laboratory Medicine Leukemia, Lymphocytic, Chronic, B-Cell - blood Leukemia, Lymphocytic, Chronic, B-Cell - immunology Lymphocyte Count Lymphoma, Non-Hodgkin - blood Lymphoma, Non-Hodgkin - immunology Male Middle Aged Non-Hodgkin's lymphomas Pathology Proteins
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Zusammenfassung:	The levels of CD19 + and CD20 + microvesicles were estimated in the blood of patients with B-cell chronic lymphocytic leukemia and indolent non-Hodgkin lymphoma by flow cytometry method. It was found that the number of B cell microvesicles is several times higher in patients than in volunteers. The level of CD20 + microvesicles directly correlated with the number of CD20 + lymphocytes in patients with chronic lymphoproliferative diseases. Extramedullary tumors cells can be a source of CD19 + microvesicles.
ISSN:	0007-4888 1573-8221
DOI:	10.1007/s10517-013-2286-y