Clinical and treatment factors determining long‐term outcomes for adult survivors of childhood low‐grade glioma: A population‐based study

BACKGROUND The determinants of outcomes for adult survivors of pediatric low‐grade glioma (PLGG) are largely unknown. METHODS This study collected population‐based follow‐up information for all PLGG patients diagnosed in Ontario, Canada from 1985 to 2012 (n = 1202) and determined factors affecting survival. The impact of upfront radiation treatment on overall survival (OS) was determined for a cohort of Ontario patients and an independent reference cohort from the Surveillance, Epidemiology, and End Results database. RESULTS At a median follow‐up of 12.73 years (range, 0.02‐33 years), only 93 deaths (7.7%) were recorded, and the 20‐year OS rate was 90.1% ± 1.1%. Children with neurofibromatosis type 1 had excellent survival and no tumor‐related deaths during adulthood. Adverse risk factors included pleomorphic xanthoastrocytoma (P