miR-206 functions as a novel cell cycle regulator and tumor suppressor in clear-cell renal cell carcinoma

Highlights • We reviewed and experimentally analyzed the currently available miRNA expression profiles data of ccRCC. • miR-206 was identified as one of the most critical tumor-suppressing microRNAs in ccRCC. • miR-206 inhibited ccRCC cell proliferation through inducing cell cycle arrest by directly...

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Veröffentlicht in:	Cancer letters 2016-04, Vol.374 (1), p.107-116
Hauptverfasser:	Xiao, Haibing, Xiao, Wei, Cao, Jing, Li, Heng, Guan, Wei, Guo, Xiaolin, Chen, Ke, Zheng, Tao, Ye, Zhangqun, Wang, Ji, Xu, Hua
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Carcinoma, Renal Cell - genetics Carcinoma, Renal Cell - metabolism Carcinoma, Renal Cell - pathology ccRCC Cell adhesion & migration Cell cycle Cell Cycle Proteins - genetics Cell Cycle Proteins - metabolism Cell growth Cell Growth Processes - genetics Cell Line, Tumor Cloning Cyclin D1 - genetics Cyclin D1 - metabolism Cyclin-Dependent Kinase 4 - genetics Cyclin-Dependent Kinase 4 - metabolism Cyclin-Dependent Kinase 9 - genetics Cyclin-Dependent Kinase 9 - metabolism G1 Phase Cell Cycle Checkpoints - genetics Gene expression Hematology, Oncology and Palliative Medicine Humans Kidney Neoplasms - genetics Kidney Neoplasms - metabolism Kidney Neoplasms - pathology Male Medical prognosis Mice Mice, Inbred BALB C MicroRNAs MicroRNAs - genetics MicroRNAs - metabolism miR-206 Molecular biology Pathogenesis Resting Phase, Cell Cycle - genetics Science Studies tumor suppressor
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Beschreibung
Zusammenfassung:	Highlights • We reviewed and experimentally analyzed the currently available miRNA expression profiles data of ccRCC. • miR-206 was identified as one of the most critical tumor-suppressing microRNAs in ccRCC. • miR-206 inhibited ccRCC cell proliferation through inducing cell cycle arrest by directly targeting cell cycle related gene CDK4, CDK9 and CCND1.
ISSN:	0304-3835 1872-7980
DOI:	10.1016/j.canlet.2016.01.032