A Major Role for TPP II in Trimming Proteasomal Degradation Products for MHC Class I Antigen Presentation
Intracellular proteins are degraded by the proteasome, and resulting peptides surviving cytoplasmic peptidase activity can be presented by MHC class I molecules. Here, we show that intracellular aminopeptidases degrade peptides within seconds, almost irrespectively of amino acid sequence. N-but not...
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Veröffentlicht in: | Immunity (Cambridge, Mass.) Mass.), 2004-04, Vol.20 (4), p.495-506 |
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Hauptverfasser: | , , , , , , |
Format: | Artikel |
Sprache: | eng |
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