Id2 and Id3 Inhibit Development of CD34 super(+) Stem Cells into Predendritic Cell (Pre-DC)2 but Not into Pre-DC1: Evidence for a Lymphoid Origin of Pre-DC2

We found previously that 10, which inhibits transcriptional activities of many basic helix-loop-helix transcription factors, blocked T and B cell development but stimulated natural killer (NK) cell development. Here we report that ectopic expression of Id3 and another Id protein, Id2, strongly inhib...

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Veröffentlicht in:The Journal of experimental medicine 2000-12, Vol.192 (12), p.1775-1784
Hauptverfasser: Spits, H, Couwenberg, F, Bakker, A Q, Weijer, K, Uittenbogaart, CH
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Sprache:eng
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Zusammenfassung:We found previously that 10, which inhibits transcriptional activities of many basic helix-loop-helix transcription factors, blocked T and B cell development but stimulated natural killer (NK) cell development. Here we report that ectopic expression of Id3 and another Id protein, Id2, strongly inhibited the development of primitive CD34 super(+)CD38 super(-) progenitor cells into CD123 super(high) dendritic cell (DC)2 precursors. In contrast, development of CD34 super(+)CD38 super(-) cells into CD4 super(+)CD14 super(+) DC1 precursors and mature DC1 was not affected by ectopic Id2 or Id3 expression. These observations support the notion of a common origin of DC2 precursors, T and B cells. As Id proteins did not block development of NK cells, a model presents itself in which these proteins drive common lymphoid precursors to develop into NK cells by inhibiting their options to develop into T cells, B cells, and pre-DC2.
ISSN:0022-1007
1892-1007