Highly Selective Oligonucleotide-Based Sensor for Mercury(II) in Aqueous Solutions

Mercury gauge: An oligodeoxyribonucleotide(ODN)‐based sensor, which carries energy‐donor and ‐acceptor moieties (fluorescein, F, and dabcyl, D, respectively), selectively detects HgII ions in aqueous solution. Upon binding HgII ions, the ODN takes on a hairpin structure (see picture); this results i...

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Veröffentlicht in:	Angewandte Chemie International Edition 2004-08, Vol.43 (33), p.4300-4302
Hauptverfasser:	Ono, Akira, Togashi, Humika
Format:	Artikel
Sprache:	eng
Schlagworte:	Biosensing Techniques - methods biosensors Environmental Pollutants - analysis fluorescence FRET (fluorescence resonance energy transfer) mercury Mercury - analysis Oligonucleotides Solutions
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Beschreibung
Zusammenfassung:	Mercury gauge: An oligodeoxyribonucleotide(ODN)‐based sensor, which carries energy‐donor and ‐acceptor moieties (fluorescein, F, and dabcyl, D, respectively), selectively detects HgII ions in aqueous solution. Upon binding HgII ions, the ODN takes on a hairpin structure (see picture); this results in a decrease in the fluorescence emission through enhanced FRET (fluorescence resonance energy transfer) from F to D.
ISSN:	1433-7851 1521-3773
DOI:	10.1002/anie.200454172